Effect of Opioid Cessation on Opioid-Induced Esophageal Dysfunction

Mayo Clinic26 enrolled

Overview

The purpose of this study is to evaluate the effect of opioid cessation on opioid-induced esophageal dysfunction (OIED).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Opioid-Induced Esophageal Dysfunction

Interventions

Opioid cessationBEHAVIORAL

opioid cessation will occur during pain rehabilitative program over approximately 3 weeks

No opioid cessationOTHER

Subjects will not stop taking opioids

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: \- Patients enrolled in the Pain Rehabilitation Center for opioid cessation, with or without esophageal symptoms. Exclusion Criteria: * Inability to provide informed consent. * Patients with previous gastroesophageal surgery or pneumatic dilation. * Esophageal botulinum toxin injection within the prior 12 months. * Esophageal stricture * Achalasia types I and II * Allergy to Lidocaine or other local anesthetics * Subjects on anticoagulation * Bilateral nasal obstruction * Pregnancy or breast feeding

Locations (1)

Mayo Clinic Minnesota

Rochester, Minnesota, United States

RECRUITING

Outcomes

Primary Outcomes

Number of subjects to have opioid-induced esophageal dysfunction resolution

Number of subjects to have resolution of opioid-induced esophageal dysfunction

Time frame: 4 weeks

Secondary Outcomes

Number of subjects with dysphagia

Number of subjects that are chronic opioid users presenting to an opioid cessation clinic to have dysphagia

Time frame: 4 weeks

Number of subjects with chest pain

Number of subjects that are chronic opioid users presenting to an opioid cessation clinic to have chest pain

Time frame: 4 weeks

Number of subjects with opioid-induced esophageal dysfunction

Number of subjects that are chronic opioid users presenting to an opioid cessation clinic to have opioid-induced esophageal dysfunction

Time frame: 4 weeks

Central Contacts

Mariah Robran

CONTACT

507-266-3595 robran.mariah@mayo.edu

Data from ClinicalTrials.gov

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