"A Comparative Clinical Evaluation of the Efficacy of Topical Adapalene, Benzoyl Peroxide Gel, Oral Lactobacillus Rhamnosus, D-chiro-inositol, Inulin Capsule, and Their Fixed Combination in Mild to Moderate Acne Vulgaris Patients."

Treatment and Diagnostic Center of Private Enterprise "Asklepiy"59 enrolled

Overview

The study aims to conduct a comparative clinical evaluation of the effectiveness of a fixed topical combination of adapalene with benzoyl peroxide in the form of a gel, a fixed combination of Lactobacillus rhamnosus, D-chiro-inositol and inulin in the form of capsules and their combination in patients with acne vulgaris of mild and moderate severity and laboratory lipid analysis profile of sebum, lipid metabolism, and IGF-1 (insulin-like growth factor).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Acne Vulgaris

Interventions

Oral Lactobacillus Rhamnosus, D-chiro-inositol, Inulin Capsule

Lactobacillus Rhamnosus 1,5 х 10\*9, Inulin 25mg, D-chiro-inositol 250mg

Topical Adapalene, Benzoyl Peroxide GelDRUG

Adapalene 1mg/g, Benzoyl Peroxide 25mg/ml

Eligibility

Sex: ALLMin age: 18 YearsMax age: 27 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with mild to moderate level of Acne Vulgaris Exclusion Criteria: * Pregnancy

Locations (1)

TDC PE "Asklepiy"

Uzhhorod, Zakarpattia Oblast, Ukraine

Outcomes

Primary Outcomes

GAGS (Global Acne Grading System)

The primary end point of the study is the intensity of acne manifestations according to the GAGS scale

Time frame: 180 days

Secondary Outcomes

IGA (Investigator Global Assessment)

The secondary end point of the study is the intensity of acne manifestations according to the IGA scale

Time frame: 180 days

Data from ClinicalTrials.gov

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