A Study to Investigate the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle

Phase 4RecruitingNCT05856136

Mayo Clinic69 enrolled

Overview

The purpose of this study is to evaluate opioid dose effects on the ability of the diaphragm muscle to generate higher force behaviors.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Respiratory Function Loss Respiratory Complication

Interventions

Fentanyl InjectionDRUG

Three different fentanyl doses (used for sedation) will be evaluated on their effects on shear wave elastography (SWE) and breathing

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: \- Adult male and female patients undergoing lower extremity orthopedic surgery at the study institutions (St. Mary Hospital and Rochester Methodist Hospital within the Mayo Clinic Rochester hospital system). Exclusion Criteria: * Patients who refuse research participation. * Patients who are pregnant. * Patients with known pulmonary pathology (COPD, asthma requiring routine treatment).

Locations (1)

Mayo Clinic Minnesota

Rochester, Minnesota, United States

RECRUITING

Outcomes

Primary Outcomes

Change in Young's modulus (derived from shear wave speed)

Measured by the ultrasound elastography of the diaphragm muscle reported in KPa

Time frame: Baseline, 10 min post-opioid

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.