Cachexia is a common complication of various advanced malignant tumors, which seriously affects the quality of life and survival time of patients. In view of the clinical problem of non-nutritional response in patients with cachexia, the investigators plan to carry out a clinical case-control study on the intervention of creatine combined with curcumin in participants with cachexia. On the whole, the investigators limited the study subjects to upper digestive tract tumors and diagnosed participants with early cachexia. The main purpose of this study is to determine whether the combination of the two can play a positive and stable role in inhibiting the inflammation of cachexia and improving metabolic status, so that basic nutrition can play a role, in order to reduce the level of skeletal muscle consumption, maintain weight, improve quality of life, save medical costs and extend survival time.
This is a prospective open controlled study. The intervention is targeted at participants with early cachexia in upper gastrointestinal tumors.Both control group and intervention group receive basic nutritional support. On the basis of this, the intervention group will be given creatine and curcumin orally.The purpose is to investigate whether creatine combined with curcumin can improve the inflammatory and the nutritional state, correct the disorder of nutrient metabolism and improve the prognosis of participants.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
152
An adequate supply of energy and protein in diet, oral nutrition supplement or tube feeding enteral nutrition supplement when diet is deficient.
Creatine and curcumin are orally added other than basic nutrition treatment.
L3 skeletal muscle index(c㎡/㎡)
CT scans L3 cross-sectional skeletal muscle area/height²
Time frame: 0-month
L3 skeletal muscle index(c㎡/㎡)
CT scans L3 cross-sectional skeletal muscle area/height²
Time frame: 1-month
Appendicular skeletal muscle mass index(kg/㎡)
Appendicular skeletal muscle mass(ASM)is measured by bioelectrical impedance analysis(BIA), the ASM index (ASM/height²)is calculated.
Time frame: 0-month
Appendicular skeletal muscle mass index(kg/㎡)
Appendicular skeletal muscle mass(ASM)is measured by bioelectrical impedance analysis(BIA), the ASM index (ASM/height²)is calculated.
Time frame: 1-month
Pre-albumin concentration(mg/L)
Serological pre-albumin concentration
Time frame: 0-month
Pre-albumin concentration(mg/L)
Serological pre-albumin concentration
Time frame: 1-month
Albumin concentration(g/L)
Serological albumin concentration
Time frame: 0-month
Albumin concentration(g/L)
Serological albumin concentration
Time frame: 1-month
Body Mass Index(kg/㎡)
body weight/height²
Time frame: 0-month
Body Mass Index(kg/㎡)
body weight/height²
Time frame: 1-month
Nutrition intake level(%)
Investigate the ratio of actual energy and protein intake levels to target intake levels
Time frame: 0-month
Nutrition intake level(%)
Investigate the ratio of actual energy and protein intake levels to target intake levels
Time frame: 1-month
PG-SGA score
Scored Patient-Generated Subjective Global Assessment(PG-SGA)：(0-1，stage A；2-8，stage B；≥9，stageC)
Time frame: 0-month
PG-SGA score
Scored Patient-Generated Subjective Global Assessment(PG-SGA)：(0-1，stage A；2-8，stage B；≥9，stageC)
Time frame: 1-month
Functional Assessment of Anorexia/Cachexia Therapy(FAACT)
Anorexia/Cachexia Sub-scale-12：score 0～24，Anorexia/Cachexia
Time frame: 0-month
Functional Assessment of Anorexia/Cachexia Therapy(FAACT)
Anorexia/Cachexia Sub-scale-12：score 0～24，Anorexia/Cachexia
Time frame: 1-month
Survival rate(%)
(Number of surviving cases after 1 month of follow-up)/(number of cases at the beginning of follow-up) ×100%
Time frame: 1-month
Survival rate(%)
(Number of surviving cases after 3 month of follow-up)/(number of cases at the beginning of follow-up) ×100%
Time frame: 3-month
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