Psychosis TMS Study

N/AActive Not RecruitingNCT05857137

Massachusetts General Hospital20 enrolled

Overview

The main goal of this study is to investigate the neural mechanisms of working memory function in patients with early psychosis using Transcranial Magnetic Stimulation (TMS) in conjunction with functional MRI. TMS is a noninvasive method used to modulate brain activity via changing magnetic fields applied over the surface of the scalp.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Psychosis

Interventions

Active TMSDEVICE

Continuous theta burst stimulation (cTBS) will be administered over the left inferior parietal lobule for approximately 3 minutes at 120% of the resting motor threshold.

Placebo TMSDEVICE

Placebo TMS will be applied over the left inferior parietal lobule for approximately 3 minutes.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of psychosis, psychosis not otherwise specified, schizophrenia, schizoaffective disorder, delusional disorder, bipolar disorder with psychosis, and schizophreniform disorder within first ten years of onset of psychotic symptoms. * Ability to provide informed consent Exclusion Criteria: * TMS incompatibility including metallic implants in head and neck, cardiac pacemakers, history of seizures, pregnancy. * MRI-incompatibility including implanted aneurism clips, cardiac pacemakers, metal implants, intrauterine devices, tattoos containing metal ink, pregnancy, and claustrophobia * Severe substance abuse within 3 months (nicotine allowed) * Unstable medical or neurologic illness that would preclude participation in study procedures

Locations (1)

Martinos Center for Biomedical Imaging

Charlestown, Massachusetts, United States

Outcomes

Primary Outcomes

Working memory accuracy

Accuracy at high memory loads during performance of the Sternberg Item Recognition Paradigm will be assessed before and after the TMS interventions.

Time frame: 2 hours

Reaction time during working memory

Reaction time during performance of the Sternberg Item Recognition Paradigm will be assessed before and after the TMS interventions.

Time frame: 2 hours

Resting state functional connectivity between the left inferior parietal lobule and the regions of the frontoparietal control network

Functional connectivity between left inferior parietal lobule and dorsolateral prefrontal cortex will be computed during resting state acquired before and after the TMS interventions.

Time frame: 2 hours

Resting state functional connectivity within the default mode network

Functional connectivity between left inferior parietal lobule and other regions of the default mode network (including the posterior cingulate cortex and the medial prefrontal cortex) will be computed during resting state acquired before and after the TMS interventions.

Time frame: 2 hours

Data from ClinicalTrials.gov

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