Clinical Outcomes of CT-FFR Versus QFR-guided Strategy for Decision-Making in Patients With Stable Chest Pain

Inclusion Criteria: * Age ≥18 years * with stable chest pain who underwent CCTA and have at least 1 lesion with a percent diameter stenosis (DS%) between 50% and 90% in a coronary artery with a ≥2.5 mm reference vessel diameter by visual assessment.These patients plan to undergo further non-invasive or invasive diagnosis and treatment. * Able to undergo invasive coronary angiography (ICA) * Capable of complying with the study procedures and fully understand the informed consent form approved by the ethics committee, and provide voluntary consent. Exclusion Criteria: General exclusion criteria: * Patients with acute coronary syndrome requiring urgent revascularization. * Patients with unstable angina, including those with first-onset chest pain within 48 hours, CCS III or higher first-onset angina, those whose angina has worsened to CCS III or IV within a short period of time, or those with rest angina lasting more than 20 minutes. * Patients with iodine contrast agent allergy. * Pregnant or lactating women. * Patients with severe congestive heart failure (NYHA III-IV or LVEF \<30%) or acute pulmonary edema. * Patients with severe renal insufficiency (creatinine \>150μmol/L or estimated - -glomerular filtration rate calculated by the Cockcroft-Gault formula \<45ml/kg/1.73 m2). * Patients with other comorbidities and an expected survival time of less than 1 year. * Patients who, for any other reason, are considered by the investigators to be unsuitable for inclusion in the study or unable to complete the study and follow-up. Coronary CTA and coronary angiography exclusion criteria: * Patients with a body mass index \>35 when undergoing coronary CT testing, resulting in poor CT image quality due to motion artifacts, severe calcification, or inadequate iodine contrast agent filling. * Patients with a history of coronary artery bypass grafting (CABG). * Target lesions related to acute myocardial infarction. * Target lesions involving left main stem disease. * Target lesions involving myocardial bridging. * Target lesions involving in-stent restenosis. * Low-quality angiography due to poor visualization of vascular boundaries or poor iodine contrast agent filling. * Excessive overlap of the stenotic segment or severe tortuosity of the target vessel, making QFR calculation impossible. Regen