Magnesium Sulphate and Extubation Quality

Cukurova University98 enrolled

Overview

The investigators aimed to search effect of magnesium Sulfate on extubation quality scores, recovery and pain in larynx micro surgery. The patients allocated to two groups to receive magnesium sulfate 30 mg/kg in 100 ml saline infusion (maximum 2g) (Group m) or saline 100 ml (Group S) before induction of anesthesia. Anesthesia induction performed with propofol 2 mg/kg, rocuronium 0.6 mg/kg, remifentanil 0.5 µg/kg and general anesthesia maintained with total intravenous anesthesia (propofol 3-7 mg/kg, remifentanil 0.05-0.1 µg/kg/min and O2/air 30/70 mixture) to the all patients. Extubation quality scores, Extubation time, NRS scores were assessed.

The investigators aimed to search effect of magnesium sulfate on extubation quality, recovery feature and complications.98 adult patients scheduled for larynx laser microsurgery were included and randomly allocated to two groups to receive magnesium sulfate 30 mg/kg in 100 ml saline infusion (maximum 2g) (Group m) or saline 100 ml (Group S) before induction of anesthesia. Anesthesia induction performed with propofol 2 mg/kg, rocuronium 0.6 mg/kg, remifentanil 0.5 µg/kg and general anesthesia maintained with total intravenous anesthesia (propofol 3-7 mg/kg, remifentanil 0.05-0.1 µg/kg/min and O2/air 30/70 mixture) to the all patients. Paracetamol 15 mg/kg applied to all patients.Extubation quality score, extubation time, stay in postanesthesia unit (PACU) time, numeric rating scale (NRS) and complications were recorded.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Perioperative Complication

Interventions

Magnesium sulfateDRUG

magnesium sulphate IV 30 mg/kg (10 min) infusion apply to the Group M

SalineDRUG

100 ml saline infusion apply to the Group S

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 age over * American society of Anesthesiology (ASA) clinical status I-III * the patients who experience larynx micro surgery Exclusion Criteria: * under 18 years old * ASA IV and over * severe airway obstruction * neuromuscular disease * presence of tracheostomy

Locations (1)

Cukurova University

Adana, Turkey (Türkiye)

Outcomes

Primary Outcomes

extubation quality scores

Extubation quality will assess with quality scores such as no cough, Mild cough, moderate cough, severe cough.

Time frame: at the time between stop the total intravenous anesthesia and extubation of patient (last 20 min of anesthesia).

Secondary Outcomes

extubation time

The time need to adequate spontaneous ventilation at recovery period

Time frame: time between stop the total intravenous anesthesia and extubation of patient (last 20 min of anesthesia).

Data from ClinicalTrials.gov

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