Zona Pellucida Bound Sperm vs. Embryologist Selected Sperm for Intracytoplasmic Sperm Injection

Inclusion Criteria: * Undergoing their first in vitro fertilization (IVF) cycle * Electing single embryo transfer * Electing preimplantation genetic testing for aneuploidy (PGT-A) of their embryos * Female partners age \<42 years old at start of vaginal oocyte retrieval cycle, but \>18 years old. * Normal ovarian reserve: * Antimullerian hormone level (AMH) ≥ 1.2 ng/mL * Antral follicle count (AFC) ≥ 8 * At least 4 mature oocytes (M2s) retrieved at the VOR procedure in order to randomize * At least 1 immature oocyteretrieved at the VOR procedure to perform ZP binding co-incubation procedure * Intention to transfer the morphological best quality, euploid, embryo at the frozen embryo transfer procedure Exclusion Criteria: * Contraindication to IVF * Clinical indication for preimplantation genetic testing (i.e., screening for single gene disorder, chromosomal translocation, or any other disorders requiring a more detailed embryo genetic analysis) * Male partner with azoospermia or oligozoospermia (\<100,000 total motile spermatozoa) * Male partner with Y-chromosome microdeletion * Male partner with any Karyotype other than 46,XY * Male partner requiring surgically obtained sperm either via testicular or epididymal retrieval procedures * Uncorrected hydrosalpinges that communicate with the endometrial cavity * Endometrial Insufficiency, as defined by a prior cycle with maximal endometrial thickness \<6mm,), or persistent endometrial fluid * Donor oocyte cycles * Gestational carriers