Effects of Probiotics on Streptococcus Mutans ve Lactobacillus Spp

Didem Sakaryali Uyar58 enrolled

Overview

To evaluate the change of S. mutans and Lactobacillus spp. counts after all dental treatments were completed under general anesthesia and compare the groups in case of using probiotics and not using probiotics with the time for 6-months follow-up period.

Fifthy-eight pediatric patients without any systemical diseases whose dental treatments were completed under general anesthesia were included in the study. The study was carried out as two-groups; Group A: Patients who started using probiotics after general anesthesia and Group B: Patients who did not use probiotics after general anesthesia. The counts of S. mutans and Lactobacillus spp. were determined by quantitative polymerase chain reaction (qPCR) by analysis of saliva samples taken from all patients on the day before the general anesthesia (T0), at 1-month (T1), 3-month (T2) and 6-month (T3) follow-up periods. The statistical significance level was accepted as p\<0.05.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Tooth Decay Probiotics Streptococcus Mutans

Interventions

Probiotic useDIETARY_SUPPLEMENT

Probiotics were used for 3 months and all participated patients were followed for 6 months.

Eligibility

Sex: ALLMin age: 2 YearsMax age: 12 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Every included child had at least 8 tooth with caries. Exclusion Criteria: * Patients who would not be able to give saliva samples due to high anxiety or lack of saliva were not included in this study.

Locations (1)

Başkent University

Ankara, Cankaya, Turkey (Türkiye)

Outcomes

Primary Outcomes

S mutans count

CFU

Time frame: 6 month

Lactobacillus spp count

CFU

Time frame: 6 month

Data from ClinicalTrials.gov

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