Prospective Validation of Clinical Prediction Model for Venous Thromboembolism Following Neurosurgery

Capital Medical University1,000 enrolled

Overview

Validation of Clinical Prediction Model for Venous Thromboembolism Following Neurosurgery: A Multicenter, Prospective, and Cohort Study

A clinical prediction model for VTE after neurosurgical procedures during hospitalization has been developed and internally retrospectively validated. A multicenter, prospective cohort study is planned to validate this clinical prediction model again.

Study Type

OBSERVATIONAL

Enrollment

1,000

Conditions

Venous Thromboembolism Neurosurgery Risk Assessment

Interventions

Clinical Prediction Model for Venous Thromboembolism Following NeurosurgeryDIAGNOSTIC_TEST

This is a clinical prediction model that uses perioperative clinical indicators and laboratory tests to predict the occurrence of VTE after neurosurgery.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. age \>18 years 2. underwent neurosurgical procedures during hospitalization 3. underwent preoperative ultrasound examination Exclusion Criteria: 1. a patient with obvious bacterial or viral infection within the past two weeks before admission 2. a patient with venous thromboembolism within the past three months before surgery 3. a patient with anticoagulant therapy (direct oral anticoagulants, low molecular weight heparin) was administered continuously or intermittently before admission 4. a patient with a prior coagulation dysfunction

Locations (1)

Sanbo Brain Hospital, Capital Medical University

Beijing, China

RECRUITING

Outcomes

Primary Outcomes

Symptomatic or asymptomatic VTE

A combination of symptomatic or asymptomatic DVT and symptomatic or asymptomatic PE

Time frame: 2023.3-2023.7

Secondary Outcomes

DVT

A blood clot within a deep vein, typically in the thigh or leg, which is detected with compressible ultrasound, venography, impedence plethysmography, radiofibrinogen uptake scanning or autopsy based on the time of study. This outcome combines proximal or distal DVT of the leg, upper limb DVT

Time frame: 2023.3-2023.7

Obstruction of a pulmonary artery or one of its branches that is usually produced by a blood clot which has originated in a vein of the leg or pelvis and traveled to the lungs, which is diagnosed by CT pulmonary angiography, ventilation-perfusion lung scanning pulmonary angiogram, or by autopsy or equivalent technology based on the time of study. This outcome combines saddle, lobar, segmental or subsegmental PE according to the anatomic location

Time frame: 2023.3-2023.7

Proximal DVT

Proximal DVT is a blood clot that is located in the popliteal, femoral, or iliac veins, which is detected with compressible ultrasound, venography, impedence plethysmography, radiofibrinogen uptake scanning or autopsy based on the time of study

Time frame: 2023.3-2023.7

Central Contacts

Deshan Liu, Dr.

CONTACT

15613318871 alfredliu@mail.ccmu.edu.cn

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.