Prognostic Value of Estimated Plasma Volume in Pulmonary Hypertension

Central Hospital, Nancy, France100 enrolled

Overview

Assessment of the prognostic value of the estimation of plasma volume or its variation in patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) after acute right heart failure.

The aim of the study is to show that a low plasma volume status, assessed by the Strauss (estimated plasma volume variation) and the Duarte (instantaneous estimated plasma volume) formulas evaluated during acute right heart failure in patients presenting with PAH or CTEPH, is associated with better long-term outcomes. Optimization of plasma volume is important for patients with PAH and CTEPH and constitutes a prognostic factor. However, plasma volume status can be difficult to assess in clinical practice. Different formulas have been developed and have shown interest in patients with congestive heart failure with an association between plasma volume estimation and long-term prognosis. Acute right heart failure may occur in patients with PAH and CTEPH. Thus, the investigators plan to study the prognostic value of these formulas evaluating plasma volume, in patients with PAH or CTEPH, after acute right heart failure.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Pulmonary Arterial Hypertension Chronic Thromboembolic Pulmonary Hypertension Acute Right Heart Failure

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients with confirmed diagnosis of PAH or CTEPH, referred to the medical department of the investigators 2. Patient with acute right heart failure defined by at least 2 of the following clinical features: worsening of peripheral oedema, development or increase of ascites, weight gain of more than 2.5 kg in 1 week preceding the visit and decline in one NYHA functional class compared to the previous stable state Exclusion Criteria: 1\) Patients with another cause of pulmonary hypertension than PAH or CTEPH, either groups 2, 3 or 5 of the current clinical classification of pulmonary hypertension

Outcomes

Primary Outcomes

Survival

Death

Time frame: From the first visit to 1st April 2023

Recurrence of acute right heart failure

Hospital admission for acute right heart failure

Time frame: From the first visit to 1st April 2023

Acute right heart failure-free survival

First event: death or hospital admission for acute right heart failure

Time frame: From the first visit to 1st April 2023

Data from ClinicalTrials.gov

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