Comparison of Patient-controlled Analgesia Regimenfor Postoperative Pain in Patients Undergoing Total Knee Arthroplasty

Chung-Ang University Gwangmyeong Hospital98 enrolled

Overview

Patients who undergoing total knee arthroplasty under spinal analgesia will be recruited and randomly assigned to the following two groups according to the regimen of PCA: (A) opioid group who receive only fentanyl citrate 1200mcg for continuous infusion drug, (B) non-opioid group who receive ketorolac tromethamine 150mg with nefopam hydrochloride 100mg for continuous infusion drug. All the patients will receive additional fentanyl citrate as bolus injection drug if they need more analgesics postoperatively.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

Conditions

Postoperative Pain, Acute

Interventions

Fentanyl

opioid group receives only fentanyl citrate 1200mcg for continuous infusion drug

ketorolac tromethamine with nefopam hydrochlorideDRUG

non-opioid group receives ketorolac tromethamine 150mg with nefopam hydrochloride 100mg for continuous infusion drug

Eligibility

Sex: ALLMin age: 60 YearsMax age: 79 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA physical status I-II * undergoing elective total knee arthroplasty under spinal anesthesia Exclusion Criteria: * history of stomack ulceration * increased ICP * bronchial asthma * allergy on aspirin, NSAIDs, Nefopam * drug user of antiplatelet or anticoagulant

Locations (1)

ChungAng University Gwangmyeong Hospital

Gyeonggi-do, Gwangmyeon-si, South Korea

Outcomes

Primary Outcomes

postoperative pain score

evaluated by visual analogue scale

Time frame: 24 hours after the surgery

Data from ClinicalTrials.gov

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