Effects of Omega-3 and Whey Protein Supplementation on Lean Mass in Older Adults

N/AActive Not RecruitingNCT05862779

Federal University of Uberlandia75 enrolled

Overview

To evaluate the effect of omega-3 supplementation combined with whey protein intake on lean mass, muscle strength, metabolomic and lipidomic profiles, and biomarkers of oxidative stress and inflammation in older adults undergoing resistance exercise. Participants will be randomized into the 4 groups. The placebo group will receive 5 g per day of sunflower oil and 38 g per day of maltodextrin. The omega 3 + placebo group will receive 5 g per day of fish oil and 38 g per day of maltodextrin. The whey protein + placebo group will receive 38g per day of whey and 5g per day of sunflower oil. The omega 3 + whey group will receive 5g per day of fish oil and 38g per day of protein. All will perform the same exercise protocol for 12 weeks.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Sarcopenia

Interventions

The placebo group will receive 5 g per day of sunflower oil and 38 g per day of maltodextrin.

Whey Protein + PlaceboDIETARY_SUPPLEMENT

The whey protein + placebo group will receive 38g per day of whey and 5g per day of sunflower oil.

Omega 3 + PlaceboDIETARY_SUPPLEMENT

The omega 3 + placebo group will receive 5 g per day of fish oil and 38 g per day of maltodextrin.

Omega 3 + Whey ProteinDIETARY_SUPPLEMENT

The omega 3 + whey group will receive 5g per day of fish oil and 38g per day of protein.

Eligibility

Sex: FEMALEMin age: 60 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Postmenopausal women (at least 1 year of menstrual interruption, self-reported); * To be able to practice strength exercises; * To be able to carry out supplementation; * Do not present physical, orthopedic or cardiovascular complications that prevent the performance of physical exercises; * No history of stroke or acute myocardial infarction; * Not being a smoker and/or alcoholic; * Do not perform hormone replacement therapy; * Do not use anti-inflammatory drugs; * To have normal kidney function; * To submit a medical certificate of health that proves that the individual is able to perform exercises. Exclusion Criteria: * Do not provide the necessary information for the development of the study; * Individuals with diseases previously diagnosed and undergoing treatment, such as type II diabetes mellitus, cancer, rheumatoid arthritis, cardiovascular, and kidney and/or liver diseases.

Locations (1)

Federal University of Uberlandia

Uberlândia, Minas Gerais, Brazil

Outcomes

Primary Outcomes

Changes in lean mass (kg) using ultrasound and dual-energy X-ray absorptiometry (DXA) in postmenopausal women

Time frame: up to 12 weeks

Secondary Outcomes

Changes in strength (kg) using dynamometer in postmenopausal women

Time frame: up to 12 weeks

Data from ClinicalTrials.gov

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