The goal of this clinical trial is to test whether food timing impacts metabolic health in healthy participants. Participants will: * complete 2 inpatient stays * be provided with test meals * have frequent blood draws
The investigators aim to investigate the influence of different food timing, without changing 24-h caloric and nutrient intake, on glucose and fat tolerance and energy expenditure in healthy people on a simulated day or night shift.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
48
Research participants will be assigned to day shift condition and Diet A-B order condition.
Research participants will be assigned to day shift condition and Diet B-A order condition.
Research participants will be assigned to simulated night shift condition and Diet A-B order condition.
Brigham and Women's Hospital
Boston, Massachusetts, United States
RECRUITINGDifference in glucose tolerance between Meal Conditions and Shift Work
Glucose incremental area under the curve (AUC) from mixed meal tests
Time frame: 24 hours
Difference in diet-induced thermogenesis between Meal Conditions and Shift Work
Postprandial energy expenditure incremental area under the curve (AUC) from mixed meal tests
Time frame: 24 hours
Difference in plasma triglyceride level between Meal Conditions and Shift Work
Triglyceride area under the curve (AUC) over 24 hours
Time frame: 24 hours
Difference in insulin sensitivity between Meal Conditions and Shift Work
Insulin sensitivity index derived from Oral Minimal Model
Time frame: 24 hours
Difference in beta-cell function between Meal Conditions and Shift Work
Beta-cell function index derived from Oral Minimal Model
Time frame: 24 hours
Difference in 24-h glycemia between Meal Conditions and Shift Work
Glucose area under the curve (AUC) based on CGM over 24 hours
Time frame: 24 hours
Difference in postprandial incretin level between Meal Conditions and Shift Work
Incretin incremental area under the curve (AUC) from mixed meal tests
Time frame: 24 hours
Difference in substrate oxidation between Meal Conditions and Shift Work
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Research participants will be assigned to simulated night shift condition and Diet B-A order condition.
Postprandial substrate oxidation incremental area under the curve (AUC) from mixed meal tests
Time frame: 24 hours
Difference in plasma free fatty acids level between Meal Conditions and Shift Work
Free fatty acids area under the curve (AUC) over 24 hours
Time frame: 24 hours