This study is aimed to enroll patients with early-stage cervical cancer (FIGO 2018 IB1-IB2) who undergo radical hysterectomy and the postoperative pathology doesn't meet Sedlis criteria or the "four-factor" model but with poorly differentiated squamous/adenocarcinoma/adenosquamous carcinoma. Patients will be randomly divided into two groups in a 1:1 ratio. The experimental group received 4 courses of paclitaxel and cisplatin (once every 3 weeks) for adjuvant chemotherapy within 4 weeks after surgery, while the control group don't not receive any adjuvant therapy but only received regular follow-up. The disease status of all patients will be evaluated within 4 weeks after the end of all treatment and every 12 weeks thereafter, including gynecological examination, laboratory indicators, imaging evaluation, and the prognosis of the two groups will be compared.
Study Type
OBSERVATIONAL
Enrollment
450
The Sun Yat-Sen Memorial Hospital of Sun Yat-Sen Universit
Guangzhou, Guangdong, China
RECRUITINGProgress Free Survival (PFS)
The time between surgery and clinical recurrence.
Time frame: 5 years
Overall Survival (OS)
The time interval between the cancer diagnosis and the death of any reason.
Time frame: 5 years
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