Preterm birth is a leading cause of neonatal mortality and morbidity. Cervical insufficiency is one factor implicated in the complex mechanisms involved in spontaneous preterm birth. Trans-abdominal insertion of a cervical cerclage suture can be used to treat cervical insufficiency. Growing evidence support that laparoscopic cerclage procedures are safe and effective. Still, many aspects of the laparoscopic cerclage remains uncertain. Therefore, the investigators plan to study the obstetric outcome from the first and subsequent pregnancies after laparoscopic cerclage in a Danish cohort from Aarhus University Hospital in a 10 years' period.
Please see attached study protocol for further desricption.
Study Type
OBSERVATIONAL
Enrollment
185
The surgical method of the laparoscopic cerclage procedure at Aarhus University Hospital previous described in a paper by Riiskjaer et al (DOI: 10.1111/aogs.12001)
Neonatal survival (defined as survival at time of discharge from hospital)
no. (reported for first, and consecutive deliveries)
Time frame: From birth until discharge, an average of 8 weeks
Number of neonates surviving with major neonatal morbidity
* Necrotising enterocolitis (NEC) (no.) * Bronchopulmonary Dysplasia (BPD) (defined as respiratory/oxygen support at postmenstrual age (PMA) 36 weeks) (no.) * Intraventricular haemorrhage (IVH) Grade III and IV (no.) * Hydrocephalus with ventriculoperitoneal (VP) shunt (no.) * Periventricular leukomalacia (no.) * Retinopathy of prematurity (ROP) (no.) (Reported for first, and consecutive deliveries)
Time frame: From birth until discharge, an average of 8 weeks
Number of pregnancies
no.
Time frame: From the laparoscopic cerclage until May 1, 2023 (two years after the enrollment period ends)
Number of miscarriages
* Early miscarriages (\<16 weeks and 0 days) (no.) * Late miscarriages (\<22 weeks and 0 days) (no.)
Time frame: From the laparoscopic cerclage until May 1, 2023 (two years after the enrollment period ends)
Deliveries
* Deliveries \<28 weeks and 0 days of an infant living (no.) * Deliveries \<32 weeks and 0 days of an infant living (no.) * Deliveries \<34 weeks and 0 days of an infant living (no.) * Deliveries \<37 weeks and 0 days of an infant living (no.) (reported for first, and consecutive deliveries)
Time frame: From birth until discharge, an average of 8 weeks
Number of uterine ruptures
no.
Time frame: From the laparoscopic cerclage until May 1, 2023 (two years after the enrollment period ends)
Time to first pregnancy (years and days)
no.
Time frame: From the laparoscopic cerclage until May 1, 2023 (two years after the enrollment period ends)
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