Effect of Different Doses of US in the Treatment of CTS

Cairo University60 enrolled

Overview

The purpose of this study was to investigate the effective dose of therapeutic ultrasound in the treatment of carpal tunnel syndrome on pain level, functional ability, motor and sensory nerve conduction parameters and pinch strength.

Carpal tunnel syndrome (CTS) is among the most common peripheral neuropathies causing the median nerve compression as it crosses the carpal tunnel, with an estimated prevalence of about 4 - 5% of the general population. Patients suffering from this syndrome mainly complain about paresthesia (pain, numbness, and tingling) in the innervation area of the median nerve in the hand which could be accompanied by weakness and atrophy of thenar muscles. Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy of the upper limb and a significant contributor to hand functional impairment and disability that could be treated through numerous approaches. Effective treatment options include conservative and surgical interventions. Carpal Tunnel Syndrome (CTS) remains a puzzling and disabling condition present in 3.8% of the general population. CTS is the most well-known and frequent form of median nerve entrapment, and accounts for 90% of all entrapment neuropathies. Physiotherapy modalities are used to help patients with CTS in many cases. They can both help to improve CTS symptoms as well as resolve the cause of the syndrome. Physiotherapy intervention may include special exercises, mobilizations, ergonomic interventions and advice for as well as electrotherapy modalities, aiming for the treatment and improvement of symptoms. Ultrasound waves have anti-inflammatory properties, stimulating nerve regeneration and improving nerve conductivity. The most common uses for US are to decrease soft tissue inflammation, increase tissue extensibility, enhance scar tissue remodeling, increase soft tissue healing, decrease pain, and decrease soft tissue swelling . The issue of selecting the nature of the ultrasonic wave has not been finally resolved. A continuous wave is more often used to reduce pain and increase the elasticity of the tissue, while a pulsed wave mode is applied to reduce swelling and to eliminate inflammation. The rate of absorption, and thus the thermal effect, is based on the tissue type encountered, the frequency of the ultrasound beam, and the intensity (W/cm2) of the ultrasonic output.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Carpal Tunnel Syndrome

Interventions

Traditional treatmentOTHER

The patients received traditional physical therapy treatment for carpal tunnel syndrome, in the form of hot packs, tendon and nerve glide exercises, and wrist splint for 4 weeks.

Therapeutic ultrasoundDEVICE

US treatment sessions were performed for 6 min per session, once a day, three days a week, for a total of 4 weeks.

Eligibility

Sex: ALLMin age: 25 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Subject's age range was 25-55 years . 2. Mild to moderate CTS, that is confirmed by neurologist or orthopedist based on results of physical examination and electrophysiological criteria; i. Mild CTS is characterized by sensory fibers involvement (sensory peak latency \> 3.6 milliseconds) with no motor fiber involvement (motor distal latency \< 4.1 milliseconds), provided that sensory nerve action potential (SNAP) is not absent. ii. Moderate CTS is characterized by involvement of both sensory and motor fibers, provided that neither of these two waves is absent . 3. Pain intensity more than 5 in visual analogue scale (VAS). Exclusion Criteria: 1. History of any trauma on the hands, neck, and shoulders within 3 months of the study onset 2. Cervical radiculopathy, peripheral polyneuropathy, or other neurological conditions. 3. Patients suffering from severe CTS according to electrophysiological criteria \-

Locations (1)

Ismailia Medical Complex

Ismailia, Egypt

Outcomes

Primary Outcomes

symptoms severity and functional status

Symptoms severity and functional status were measured by Boston carpal tunnel syndrome questionnaire. The patients rated their ability to perform the activity on a scale that ranged from 1 (no difficulty with the activity) to 5 (cannot perform the activity at all).

Time frame: Four weeks

median nerve motor distal latency

Electrodiagnostic tests were used to measure median nerve motor distal latency in milliseconds.

Time frame: Four weeks

median nerve motor amplitude

Electrodiagnostic tests were used to measure motor amplitude in millivolt.

Time frame: Four weeks

median nerve sensory distal latency

Electrodiagnostic tests were used to measure median nerve sensory distal latency in milliseconds.

Time frame: Four weeks

median nerve sensory amplitude

Electrodiagnostic tests were used to measure sensory amplitude in millivolt

Time frame: Four weeks

Pain intensity

Pain intensity was measured by visual analogue scale. Scores are based on self-reported measures of symptoms that are recorded with a single handwritten mark placed at one point along the length of a 10-cm line that represents a continuum between the two ends of the scale-"no pain" on the left end (0 cm) of the scale and the "worst pain" on the right end of the scale (10 cm).

Time frame: Four weeks

Pinch strength

Pinch dynamometer was used to measure pinch strength

Time frame: Four weeks

Data from ClinicalTrials.gov

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