Phthalates and bisphenols have been detected in a range of infant care products. This pilot study will test whether intervening on these sources of exposure during the critical period of minipuberty affects infants' body burden of phthalates and bisphenols. Investigators will recruit 10 participants from the ongoing NYU Children's Health and Development Study (CHES) cohort study who are \>=37 weeks gestation, carrying a male fetus, and intending to breastfeed. Investigators will randomly assign them to use either conventional baby products or phthalate- and bisphenol-free baby products for the first three months of their children's lives. Toward the end of the intervention, investigators will collect maternal breast milk and infant urine, and assay samples for phthalate metabolite and bisphenol concentrations.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
10
3-month supply. Products include wipes and diaper cream.
Subscription to cloth diaper service.
3-month supply.
Products include wipes and diaper cream.
Sunset Park Family Health Center at NYU Langone - Second Avenue
Brooklyn, New York, United States
Tisch Hospital
New York, New York, United States
Log Signal Intensity of Bisphenol A (BPA) in Child Urine Samples
Child urine samples were analyzed for bisphenols and for phthalate metabolites via non-targeted HPLC-MS/MS. The log signal intensity, an arbitrary unit, is a measurement of the signal strength of BPA in child urine; as the concentration of BPA increases, the signal intensity increases proportionally in a logarithmic fashion; higher values indicate greater infant exposure to bisphenol.
Time frame: Month 3
Log Signal Intensity of Bisphenol A (BPA) in Maternal Urine Samples
Maternal urine samples were analyzed for bisphenols and for phthalate metabolites via non-targeted HPLC-MS/MS. The log signal intensity, an arbitrary unit, is a measurement of the signal strength of BPA in child urine; as the concentration of BPA increases, the signal intensity increases proportionally in a logarithmic fashion; higher values indicate greater maternal exposure to bisphenol.
Time frame: Month 3
Mean Concentrations of Monomethyl Phthalate (mMP) in Child Urine Samples
Child urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
Mean Concentrations of Monomethyl Phthalate (mMP) in Maternal Urine Samples
Maternal urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
Mean Concentrations of Monoethyl Phthalate (mEP) in Child Urine Samples
Child urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
Mean Concentrations of Monoethyl Phthalate (mEP) in Maternal Urine Samples
Maternal urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
Mean Concentrations of Phthalic Acid (PA) in Child Urine Samples
Child urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
Mean Concentrations of Phthalic Acid (PA) in Maternal Urine Samples
Maternal urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
Mean Concentrations of Mono-(2-ethyl-5-hydroxyhexyl) Phthalate (mEHHP) in Child Urine Samples
Child urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
Mean Concentrations of Mono-(2-ethyl-5-hydroxyhexyl) Phthalate (mEHHP) in Maternal Urine Samples
Maternal urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
Mean Concentrations of Mono-carboxy-isooctyl Phthalate (mCIOP) in Child Urine Samples
Child urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
Mean Concentrations of Mono-carboxy-isooctyl Phthalate (mCIOP) in Maternal Urine Samples
Maternal urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
Mean Concentrations of Monobutyl Phthalate (mBP) in Child Urine Samples
Child urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
Mean Concentrations of Monobutyl Phthalate (mBP) in Maternal Urine Samples
Maternal urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
Mean Concentrations of Mono-iso-butyl Phthalate (mIBP) in Child Urine Samples
Child urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
Mean Concentrations of Mono-iso-butyl Phthalate (mIBP) in Maternal Urine Samples
Maternal urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
Mean Concentrations of Mono(5-carboxy-2-ethylpentyl) Phthalate (mECPP) in Child Urine Samples
Child urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
Mean Concentrations of Mono(5-carboxy-2-ethylpentyl) Phthalate (mECPP) in Maternal Urine Samples
Maternal urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
Mean Concentrations of Mono-(2-ethyl-5-oxohexyl) Phthalate (mEOHP) in Child Urine Samples
Child urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
Mean Concentrations of Mono-(2-ethyl-5-oxohexyl) Phthalate (mEOHP) in Maternal Urine Samples
Maternal urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
Mean Concentrations of Bisphenol S (BPS) in Child Urine Samples
Child urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
Mean Concentrations of Bisphenol S (BPS) in Maternal Urine Samples
Maternal urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
Mean Concentrations of Mono-carboxy-isononyl Phthalate (mCINP) in Maternal Urine Samples
Maternal urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
Mean Concentrations of Ono-carboxy-isononyl Phthalate (mCINP) in Child Urine Samples
Child urine samples were analyzed for bisphenols and for phthalate metabolites via targeted LC-MS/MS.
Time frame: Month 3
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