This study will assess the safety and efficacy of ATH434 in participants with a clinical diagnosis of Multiple System Atrophy
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
10
ATH434 taken by mouth two times per day
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Change in brain volume as measured by MRI
Time frame: Change from Baseline to Week 52
Change in iron content in substantia nigra as measured by MRI
Time frame: Change from Baseline to Week 52
Change in Unified MSA Rating Scale (UMSARS) Score
Time frame: Change from Baseline to Week 52
Change in Patient Global Impression of Change (PGI-C)
Time frame: Change from Baseline to Week 52
Change in Clinical Global Impression of Change (CGI-C)
Time frame: Change from Baseline to Week 52
Change in Neurofilament Light Chain Levels
Time frame: Change from Baseline to Week 52
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