This project will determine the independent and combined effects of aerobic exercise and time restricted fasting on cardiovascular risks among sedentary middle-aged and elderly adults. The online intervention period will be eight weeks. Before and after the intervention, arterial stiffness, cardiac autonomic nervous, body composition, glucolipid metabolism, sleep and eating habits, inflammatory reaction, sedentary behavior and physical activity level will be measured and compared between groups who are doing either aerobic exercise, time restricted fasting, both aerobic exercise and time restricted fasting, or who are in a control group. Adverse reaction, sleep and eating quality, life quality and adherence to the interventions and hunger/satiety will also be measured.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
56
Three weekly, supervised exercise sessions with aerobic exercise. Each session will last for 60-65 minutes, each period will be consist of 5 min warm up, 45 min formal training and 5-10 min relaxation training. Intervention period will be eight weeks.
Restricted daily window of caloric intake to maximum 8 hours. Intervention period will be eight weeks.
Guangzhou Sport University
Guangdong, Guangzhou, China
Change of cardiovascular risk estimated by heart rate variability
Time frame: From baseline to after 8 weeks intervention
Change of cardiovascular risk estimated by ankle-brachial index
Time frame: From baseline to after 8 weeks intervention
Change of cardiovascular risk estimated by pulse wave velocity
Time frame: From baseline to after 8 weeks intervention
Change of cardiovascular risk estimated by flow-mediated transition
Time frame: From baseline to after 8 weeks intervention
Change of cardiovascular risk estimated by cytokines level
Fasting matrix metalloproteinases, norepinephrine, and neuropeptide Y cytokines level in blood
Time frame: From baseline to after 8 weeks intervention
Weight
In kg
Time frame: From baseline to after 8 weeks intervention
body fat
In kg
Time frame: From baseline to after 8 weeks intervention
Lean body mass
In kg
Time frame: From baseline to after 8 weeks intervention
Body mass Index
In kg/m\^2
Time frame: From baseline to after 8 weeks intervention
Body fat percentage
In percent of total body mass
Time frame: From baseline to after 8 weeks intervention
Diet habits
Self-reported: diet habits were assessed using the Adult Eating Behavior Questionnaire (AEBQ). With higher scores indicating worse eating habits (represented by emotional over-eating and emotional under-eating) or better dietary (represented by food responsiveness, enjoyment of food, satiety responsiveness, food fussiness and slowness in eating).
Time frame: From baseline to after 8 weeks intervention
Sleep quality
Self-reported: sleep quality was indicated by the Pittsburgh Sleep Quality Index (PSQI) Questionnaire. The maximum score of the sleep quality index is 21 points,scores higher than 5 indicate poor sleep quality, with higher scores indicating poorer sleep quality.
Time frame: From baseline to after 8 weeks intervention
Life quality
Self-reported: life quality was indicated by The World Health Organization Quality of Life (WHOQOL)-BREF Questionnaire. With higher scores indicating better life quality.
Time frame: From baseline to after 8 weeks intervention
Physical activity
Physical activity were measured by using accelerometer (ActiGraph GT3X+ model, USA).Measured by using accelerometer (ActiGraph GT3X+ model, USA). Accelerometer was used for 7 consecutive days, being affixed to the nondominant wrist.
Time frame: From baseline to after 8 weeks intervention
Sedentary activity
Sedentary activity were measured by using accelerometer (ActiGraph GT3X+ model, USA).Measured by using accelerometer (ActiGraph GT3X+ model, USA). Accelerometer was used for 7 consecutive days, being affixed to the nondominant wrist.
Time frame: From baseline to after 8 weeks intervention
Inflammation level
Inflammation level were measured by Enzyme-linked immuno sorbent.
Time frame: From baseline to after 8 weeks intervention
Cholesterol in blood
Total fasting cholesterol in blood
Time frame: From baseline to after 8 weeks intervention
High density lipoprotein in blood
Fasting high density lipoprotein in blood
Time frame: From baseline to after 8 weeks intervention
Low density lipoprotein in blood
Fasting low density lipoprotein in blood
Time frame: From baseline to after 8 weeks intervention
Triglycerides in blood
Fasting triglycerides in blood
Time frame: From baseline to after 8 weeks intervention
Diet in take
Self-reported: Mint Health application.
Time frame: From baseline to after 8 weeks intervention
Adherence to intervention
Self-reported: WeChat application, number of completed exercise sessions out of those prescribed, in percentage.
Time frame: From baseline to after 8 weeks intervention
Adverse reaction
Self-reported: mini program.
Time frame: From baseline to after 8 weeks intervention
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