Awake Prone Positioning for COVID-19 Acute Hypoxaemic Respiratory Failure

Mohammed VI University Hospital1,069 enrolled

Overview

The objective of our study is to evaluate the effectiveness of prone position in preventing intubation or death in spontaneously ventilated patients with COVID-19 with acute respiratory failure.

The COVID-19 pandemic has challenged the management of hypoxemic respiratory failure as limited ICU capacity is strained by a new high-mortality disease and large numbers of patients requiring prolonged periods of hospitalization, as well as respiratory support equipment such as ventilators and intensive care unit (ICU) beds. If early and prolonged prone positioning (DV) reduces mortality in invasively ventilated patients with acute respiratory distress syndrome (ARDS), its role in conscious patients (DV vigil) remains a subject of debate and research. This is a retrospective, monocentric, descriptive and analytical cohort conducted over a period of 22 months from March 2020 to December 2021 and involving 1069 patients hospitalized in the intensive care unit of the CHU Mohammed VI of Oujda for the management of acute respiratory failure caused by COVID-19.

Study Type

OBSERVATIONAL

Enrollment

1,069

Conditions

Survival, Prosthesis Oxygen Deficiency

Interventions

Prone positionOTHER

Each prone position session had a minimum duration of one hour and a maximum duration of 12 hours for a minimum of 3 hours per day.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * all patients (1069 patients) with ARDS due to SARS-cov2, confirmed by nasopharyngeal swab, who were hospitalized in the COVID-19 ICU from March 1, 2020 to December 31, 2021 Exclusion Criteria: * Patients with negative CRP * Younger than 18 years of age * Patients who died or intubated on the day of admission * Patients presented a contraindication

Locations (1)

Amine Elmouhib

Oujda, Morocco

Outcomes

Primary Outcomes

Evaluate the effectiveness of awake prone position in preventing intubation or death in spontaneously ventilated patients with COVID-19 with acute respiratory failure.

Time frame: 22 months

Secondary Outcomes

length of stay in intensive care unit, length of time from hospitalization to death, length of time from hospitalization to intubation.

Time frame: 22 months

Data from ClinicalTrials.gov

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