BPB-101 in Subjects With Metastatic or Locally Advanced Solid Tumors

Inclusion Criteria: 1. Subjects voluntarily participate in the trial and sign an informed consent form. 2. Male or female subjects aged between 18 and 75 years. 3. Subjects with cytologically or histologically confirmed advanced solid tumor for which no standard therapy is available or standard therapy has failed in dose-escalation phase; In the dose-expansion phase, subjects enrollment included, but not limited to, with non-small-cell lung, esophageal, colorectal, endometrial, melanoma, bladder, and breast cancers (actual enrollment could be determined based on available data). 4. Life expectancy \>= 12 weeks. 5. Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1. 6. Participants enrolled in the dose-escalation phase (phase Ia) must have evaluable disease per RECIST 1.1. Participants enrolled in the dose expansion and clinical expansion phase (phase Ib and II) must have at least one measurable disease per RECIST 1.1. 7. Adequate hematologic and organ function at screening, as follows: 1. Absolute neutrophil count (ANC)≥1.5×10\^9/L, Platelets≥100×10\^9/L, Hemoglobin≥9g/dL(90g/L) 2. Serum total bilirubin ≤1.5×upper limit of normal (ULN), unless liver cancer or liver metastases are present, then values must be ≤2×ULN; Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤2.5×ULN, unless liver cancer or liver metastases are present, then values must be ≤5×ULN 3. Serum creatinine≤1.5×ULN OR creatinine clearance (CrCl)≥50ml/min (using the Cockcroft-Gault formula) 4. International normalized ratio (INR) and prothrombin time ≤1.5×ULN; And activated partial thromboplastin time (aPTT) ≤1.5×ULN. 8. Female subjects with childbearing potential must have a negative serum pregnancy test at screening (within 7 days of first dose of study drug). Female subjects with childbearing potential and male subjects with a female partner(s) of childbearing potential must agree to use highly effective contraceptive measures throughout the trial starting with the screening visit through 6 months after the last dose of study drug is received. Exclusion Criteria: 1. Known hypersensitivity to any component and excipients of the investigational drug, or previous severe allergic reaction to any macromolecular monoclonal antibody. 2. Received anti-PD-1 or PD-L1 antibodies within 3 months prior to screening. Previously received treatment targeting TGF-β, TGF-β receptors, or GARP. 3. Received other antitumor therapies, such as chemotherapy, biological therapy, endocrine therapy, etc., within 4 weeks before the first dose. Local palliative treatment (such as local surgery or radiotherapy) for isolated lesions can be received without affecting the efficacy evaluation. Enrollment is permitted in the following cases: * Oral pyrimidine or small molecule targeted therapy drugs are used more than 2 weeks or 5 half-lives of the drug (whichever is longer) before the first dose. * Nitrosourea or mitomycin C are used more than 6 weeks before the first dose. 4. Major surgery within 4 weeks before first dose of study drug. 5. Systemic therapy with immunosuppressive agents within 2 weeks prior to the first dose of study drug or during the study, except for corticosteroid nasal sprays, inhalers, or ≤10 mg/day systemic prednisone and equivalent medications. 6. Previous malignant disease (other than the target malignancy to be investigated in the trial) within the last 5 years.Except for malignancies that can be expected to heal after treatment (including but not limited to, adequately treated thyroid cancer, carcinoma in situ of the cervix, basal or squamous cell skin cancer, or carcinoma in situ of the breast duct treated with radical surgery). 7. Presence of symptomatic central nervous system metastases, meningeal metastases, or spinal cord compression due to metastases. Except for patients with brain metastases who have symptoms before the first dose, but whose disease is stable for ≥ 4 weeks after treatment. 8. Subjects with a clear bleeding tendency, such as gastrointestinal bleeding, hemorrhagic gastric ulcer; Those with a history of melena and hematemesis within 2 months before administration; Researchers believe that visceral bleeding may occur. 9. Patients with large and uncontrolled pleural effusions, pericardial effusions, or abdominal effusions requiring repeated drainage. 10. Has an active autoimmune disease requiring systemic treatment within 2 years prior to initial medication. 11. Cardiovascular diseases of clinical significance, including: a. Clinically uncontrolled hypertension; The following conditions occurred within 6 months before the first medication: 1. Congestive heart failure (New York Heart Association Grade III or IV); 2. Arrhythmias or conduction abnormalities that require medical treatment. Note: Subjects with drug-controlled atrial fibrillation/atrial flutter and pacemaker controlled arrhythmia can be enrolled; 3. Severe/unstable angina, coronary/peripheral bypass graft, or myocardial infarction; (Note: Severe angina is Grade III or IV of the Canadian Cardiovascular Society) 4. Cerebrovascular accident or transient ischemic attack, transient myocardial ischemia; 5. Any other arterial thrombosis or embolic event. 12. Severe active infection within 2 weeks prior to initial administration, or systemic anti-infection therapy lasting more than 7 days after intravenous use within 1 week prior to initial administration. 13. Toxicity due to previous antitumor therapy has not returned to CTCAE 5.0 level ≤1 (except for toxicity such as alopecia where the investigator determined no safety-related risk). 14. There is active tuberculosis, or interstitial lung disease requiring treatment. 15. History of bone marrow allotransplantation or solid organ transplantation. 16. HIV-positive or active syphilis infection. 17. Have active hepatitis B and C. 18. Pregnant or lactating women. 19. Have received live or attenuated vaccine within 180 days prior to initial administration of study drug (Note: Inactivated virus vaccine is allowed. Seasonal flu vaccines that do not contain live viruses are allowed. Inactivated COVID-19 vaccine is allowed, but needs to be eluted for 1 week before first administration). 20. Any other disease or condition of clinical significance that the investigator believes may affect protocol compliance or the subject's signing of informed consent, or may be inappropriate for participation in the clinical trial. 21. Inability or unwillingness to follow the research and/or follow-up procedures outlined in the programme.