The aim of the study is to compare the effects of Krill Oil and Fish Oil supplementation on muscle function in older adults. The secondary aim is to investigate the mechanisms underlying the beneficial effects previously observed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
61
EPA rich fish oil
Superba Krill Oil
Mixed vegetable oil
Stuart Robert Gray
Glasgow, Scotland, United Kingdom
Change in knee extensor maximal isometric torque ( MVC)
Knee extensor maximal isometric torque measured during a maximal voluntary contraction
Time frame: Change from baseline to 16 weeks
Change in fat mass
Whole body fat mass measured by measured via bio-electrical impedance
Time frame: Change from baseline to 16 weeks
Change in lean mass
Whole body lean mass measured by measured via bio-electrical impedance
Time frame: Change from baseline to 16 weeks
Blood sample
Red Blood Cell Omega-3 levels
Time frame: Change from baseline to 16 weeks
Change in Grip strength
Grip strength measured with a hand held dynamometer
Time frame: Change from baseline to 16 weeks
Change in Muscle thickness
Vastus lateralis muscle thickness measured by ultrasound
Time frame: Change from baseline to 16 weeks
Force steadiness during submaximal isometric knee extensor contractions
Measured by using intramuscular iEMG
Time frame: Change from baseline to 16 weeks
Neuromuscular Junction (NMJ)
Measured by iEMG
Time frame: Change from baseline to 16 weeks
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Change in gait speed
Time taken to walk 4 metres at a normal walking pace
Time frame: Change from baseline to 16 weeks
Change in Chair rise time
A 30-second sit-to-stand test measured functional abilities
Time frame: Change from baseline to 16 weeks