Changes in Gene Expression and Prognosis of Blood Immune Cells After Cardiopulmonary Bypass Surgery

Second Affiliated Hospital, Zhejiang University, School of Medicine12 enrolled

Overview

The goal of this observational study is to learn about the changes in gene expression in blood immune cells in after cardiac surgery with cardiopulmonary bypass.The main question it aims to answer is: What specific gene expression changes predict kidney damage after cardiac surgery with cardiopulmonary bypass. Participants received conventional treatment.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Acute Kidney Injury

Interventions

Gene sequencingOTHER

Participants were taken blood samples for gene sequencing at three time periods: before, after, and 24 hours after the end of the surgery

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 1\) Age≥ 18 years old; 2) Cardiopulmonary bypass descending valve replacement (molding), or coronary artery bypass grafting, or macrovascular surgery. Exclusion Criteria: * 1\) any cognitive or mental impairment that is unable to sign the informed consent form; 2) Have basic immune system and blood system diseases; 3) pregnancy; 4) Receiving radiotherapy and chemotherapy before surgery; 5) Receiving immunosuppressive drugs within six months; 6) Have participated in other interventional clinical trials within 30 days before surgery. Exit Criteria: 1. Incomplete surgery; 2. Secondary transfer in the operating room; 3. Automatically request to terminate the test.

Locations (1)

The Second Affiliated Hospital of Zhejiang University anesthesiology department

Hangzhou, Zhejiang, China

RECRUITING

Outcomes

Primary Outcomes

Postoperative acute kidney injury

SCr was elevated ≥ 26.5 micromol/L or 1.5 times the baseline for SCr ≥ or urine output \< 0.5 mL/kg/hour within 6 hours within 48 hours

Time frame: Within 48 hours after surgery

Data from ClinicalTrials.gov

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