The present study is aimed to explore the treatment effect from the intake of probiotic Lactobacillus crispatus M247 in the improvement of clinical and psychological aspects in women undergoing homologous level 2 ART procedures.
The use of assisted reproductive technology (ART) has increased dramatically worldwide due to the continuous rise in infertility rates; for these reasons an increasing number of couples undertake the path of ART, even though this is difficult journey, with uncertain outcomes and possible medical risks, both physical and psychological. In this study the investigators aim to explore the hypothesis that recreating a favorable vaginotype through the intake of the probiotic Lactobacillus crispatus M247 can have a positive effect in achieving pregnancy in cryopreserved cycles as well as a positive relationship between vaginal, endometrial (still unknown), gut and oral microbiota.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
160
Patient who have received probiotic Lactobacillus crispatus M247
ART center, Hospital of Conegliano
Treviso, Italy
Pregnancy
Rate of pregnancy
Time frame: up to 12 months
Effect on sex hormonal profile
change in anti-mullerian hormone levels
Time frame: up to 12 months
Effect on sex hormonal profile
Change in Follicle Stimulating Hormone levels
Time frame: up to 12 months
Effect on sex hormonal profile
Change in Free testosterone levels
Time frame: up to 12 months
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