This is a multicenter, observational cohort study in China with both primary prospective data collection and retrospective collection of prior treatment information from medical records, which enrolls and follows patients who are newly diagnosed with unresectable stage IIIB/IIIC/IV Non-Small-Cell Lung Cancer (NSCLC) in the selected sites. This study aims to describe the clinical practice and long-term survival benefits of patients newly diagnosed with unresectable stage IIIB/IIIC/IV NSCLC. The study also seeks to explore the condition of biomarker tests utilization, and to assess potential economic impact on patients in the real world. The safety related events will also be summarized in this study.
Study Type
OBSERVATIONAL
Enrollment
1,200
Cancer Hospital Chinese Academy of Medical Sciences.
Beijing, China
Beijing Chest Hospital
Beijing, China
Sichuan Provincial Cancer Hospital
Chengdu, China
Harbin Medical University Cancer Hospital
Harbin, China
Shandong Cancer Hospital
Jinan, China
Jiangsu Province Hospital (the First Affiliated Hospital With Nanjing Medical University)
Nanjing, China
Guangxi Cancer Hospital of Guangxi Medical University
Nanning, China
The Fourth Hospital of Hebei Medical University
Shijiazhuang, China
Shanxi Province Cancer Hospital
Taiyuan, China
Hubei Cancer Hospital
Wuhan, China
...and 2 more locations
Median Overall Survival (OS)
OS is defined as the time from the date of the first administration of anti-cancer treatment until the date of death from any cause.
Time frame: Up to 2 years
Median weeks on first-line treatment
First-line treatment will be reported by class of treatment. Median, minimum, and maximum values will be used to summarize the number of weeks on the first line of treatment.
Time frame: Up to 2 years
Tumor Molecular Characteristics, measured by the presence of defined biomarkers
The defined biomarkers to be identified are EGFR mutations, ALK rearrangement, ROS1 rearrangement, BRAF mutation, neurotrophic tyrosine receptor kinase \[NTRK\] gene fusion, KRAS mutations, and MET mutations. RET rearrangement, ERBB2 (HER2) mutation, and PD-L1 expression.
Time frame: Up to 2 years
Treatment Cost to the Participant, measured by accrued fees; pharmacy fee, treatment fee, examinations fee, insurance coverage, and other medical costs
Time frame: Up to 2 years
Number of participants with at least one adverse event, with severity determined according to National Cancer Institute Common Terminology Criteria for Adverse Events, Version 5.0 (NCI-CTCAE v5.0)
Time frame: Up to 2 years
Anti-cancer Treatment Duration
Time frame: Up to 2 years
Number of Cycles of Anti-cancer Treatment
Time frame: Up to 2 years
Number of Dose Modifications of Anti-Cancer Treatment
Time frame: Up to 2 years
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