Cross-sectional Study of Chinese Liver Cancer Patients

The Nethersole School of Nursing120 enrolled

Overview

The goal of this cross-sectional study is to investigate the prevalence and risk factors of anxiety and depression and their relationships with immune functions and quality of life among liver cancer patients in the COVID-19 pandemic era. The objectives of this study are: 1. To examine the prevalence of anxiety and depression among patients with liver cancer during the COVID-19 pandemic. 2. To identify risk factors associated with anxiety and depression among these patients. 3. To determine the association between anxiety, depression, immune function, and quality of life among liver cancer patients. Participants will be asked to fill a digital questionnaire.

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

Liver Cancer

Interventions

No interventionOTHER

Observational study. No intervention will be adopted.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion criteria Participants must meet all the following criteria for study entry: 1. Aged 18 or older. 2. Participants have a confirmed diagnosis of liver cancer in the medical records. 3. Participants are able to communicate with Chinese. Exclusion criteria Participants who meet any of the following criteria will be excluded from study entry: 1. Participant has multiple organ failure which makes him/her incapable to comply with the study protocol. 2. Participant has hepatic encephalopathy or severe mental disorder which makes him/her incapable of understanding the meanings of the questionnaires.

Locations (1)

Zhuhai People's Hospital

Zhuhai, Guangdong, China

Outcomes

Primary Outcomes

Anxiety score

Participants' anxiety status with HADS

Time frame: Baseline

Depression score

Participants' depression status with HADS

Time frame: Baseline

Secondary Outcomes

Quality of life score (The EORTC QLQ-C30)

The European Organization for Research and Treatment of Cancer(EORTC) Quality of Life Questionnaire results. Scores range from 0 to 100. A higher score represents a higher ("better") level of functioning, or a higher ("worse") level of symptoms.

Time frame: Baseline

Quality of life score (The EORTC QLQ-HCC18)

The Hepatocellular Carcinoma Module of The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire. Scores range from 0 to 100. A higher score represents a high level of symptomatology or problems.

Time frame: Baseline

Immune variables 1

White blood cell counts (WBC). Collected from daily medical records.

Time frame: Baseline

Immune variables 2

Total neutrophil count. Collected from daily medical records.

Time frame: Baseline

Immune variables 3

Total lymphocyte count. Collected from daily medical records.

Time frame: Baseline

Immune variables 4

Total monocyte count. Collected from daily medical records.

Time frame: Baseline

Immune variables 5

Neutrophilic granulocyte percentage. Collected from daily medical records.

Time frame: Baseline

Immune variables 6

Percentage of lymphocytes. Collected from daily medical records.

Time frame: Baseline

Immune variables 7

Monocyte percentage. Collected from daily medical records.

Time frame: Baseline

Immune variables 8

C-reactive protein (CRP). Collected from daily medical records.

Time frame: Baseline

Data from ClinicalTrials.gov

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