Effect of Inhaled Nitric Oxide on Pulmonary Ventilation/Perfusion Ratio Assessed by EIT in Patients With ARDS

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology30 enrolled

Overview

Electrical impedance tomography was used to monitor changes in pulmonary perfusion distribution and V/Q ratio before and after iNO in patients with acute respiratory distress syndrome to investigate the factors predicting iNO reactivity and the physiological mechanism underlying changes in oxygenation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Critical Illness

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients aged ≥ 18 years; 2. Patients are intubated and mechanically ventilated. Exclusion Criteria: 1. EIT contraindications such as chest wound dressing, pacemaker installation, defibrillator, etc; 2. With a history of cerebral hemorrhage in the past half year, as well as bleeding in any site of the body; 3. Pneumothorax; 4. Medium or massive pleural effusion; 5. Refractory shock; 6. Pregnant 7. With chronic kidney disease 8. Atrial fibrillation or other malignant arrhythmia leads to a decrease in cardiac output; 9. Failure to sign informed consent

Locations (1)

Hongling Zhang

Wuhan, Hubei, China

RECRUITING

Outcomes

Primary Outcomes

Lung ventilation/perfusion ration

Lung ventilation/perfusion ration after iNO assessed by EIT

Time frame: 3 hours