Multimodal Model for Efficacy Prediction Cetuximab in Colorectal Cancer Liver Metastasis Patient

Inclusion Criteria: 1. Age 18-75 years; 2. Histologically proven colorectal adenocarcinoma; 3. Simultaneous liver-limited metastases; 4. Initially unresectable liver metastases determined by a local MDT; 5. Life expectancy of \> 6 months; 6. RAS and BRAF V600E wild-type; 7. ECOG 0-1; 8. Available CT imaging before treatment. Exclusion Criteria: 1. Previous systemic treatment for metastatic disease; 2. Previous surgery for metastatic disease; 3. Extrahepatic metastases; 4. Unresectable primary tumor; 5. Major cardiovascular events (myocardial infarction, severe/unstable angina, congestive heart failure, CVA) within 12 months before randomisation; 6. Acute or subacute intestinal obstruction; 7. Second primary malignancy within the past 5 years; 8. Drug or alcohol abuse; 9. No legal capacity or limited legal capacity; 10. Uncontrolled hypertension, or unsatisfactory blood pressure control with ≥3 antihypertensive drugs;