To observe the effect of warm needling combined with electroacupuncture on the ovulation promotion rate and pregnancy rate in luteinized unruptured follicle syndrome (LUFS).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
70
Treatment begins on the 5th day of the menstrual cycle, qd (once a day), usually for 6-8 consecutive days, and continuing to the day of ovulation.
Letrozole tablets were given at 2.5mg (Jiangsu Hengrui Pharmaceutical Co., Ltd., H19991001, 2.5mg per tablet), po (oral), qd, for 5-7 consecutive days. When the diameter of follicles reaches 18mm, Chorionic gonadotrophin is given at 5000u (Lizhu Group Lizhu Pharmaceutical Factory, Chinese medicine H44020668, 5000u per branch), with intramuscular injection, qd, to promote follicle discharge. Patients were also instructed to have sexual intercourse on the same day and on day 2.
Fanghua Yang
Liuchow, Guangxi, China
Ultrasound characteristics of ovulation
Monitoring follicular intima thickness
Time frame: About 10 days on average until ≥18mm follicle disappears or 20mm follicle volume decreases
vaginal B-ultrasound to monitor follicles (size and discharge) and endometrial thickness on the fifth day of menstruation
vaginal B-ultrasound to monitor follicles (size and discharge) and endometrial thickness on the fifth day of menstruation
Time frame: the endometrium of ≥8mm on the fifth day of menstruation
Use vaginal B-ultrasound to monitor follicles (size and discharge) and endometrial thickness on the fifth day of menstruation
When the follicle size reached 18mm and Chorionic gonadotrophin was injected
Time frame: 48 hours after chorionic gonadotropin injection
Pregnancy judgment
Pregnancy was determined by detecting serum HCG (human chorionic gonadotropin) 14 days after ovulation
Time frame: 14 days after ovulation
Pregnancy judgment
At about 50 days of pregnancy, pregnancy sac or fetal heart beat through vaginal B ultrasound
Time frame: about 50 days of pregnancy
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