PRediction Of Five Usual Tumors Using Blood Test for Risk Assessment and Early Detection

Inclusion Criteria for Cancer Arm Participants: * 40-75 years old * Ability to provide a written informed consent * Confirmed cancer diagnosis within 30 days after study blood draw, based upon assessment of a pathological specimen * Have not received any systemic or local antitumor therapy, including but not limited to surgical resection, radiotherapy, hormone therapy, targeted therapy, immunotherapy, interventional therapy, etc. Exclusion Criteria for Cancer Arm Participants: * Pregnancy or lactating women * Known prior or current diagnosis of other types of malignancies comorbidities * Acute exacerbation of inflammatory condition or severe infection requiring therapy in hospital within 14 days prior to blood draw * Recipients of organ transplant or prior non-autologous (allogeneic) bone marrow transplant or stem cell transplant * Recipients of blood transfusion within 30 days prior to study blood draw * Poor health status or unfit to tolerate blood draw Inclusion Criteria for Non-Cancer Arm Participants: * 40-75 years old * Ability to provide a written informed consent * With clinically and/or pathologically diagnosed benign disease as defined by the protocol or self-reported no history of tumor and no signs of tumor as determined clinically Exclusion Criteria for Non-Cancer Arm Participants: * Pregnancy or lactating women * Any tumor history of benign or malignancies * Acute exacerbation of inflammatory condition or severe infection requiring therapy in hospital within 14 days prior to blood draw * Recipients of organ transplant or prior non-autologous (allogeneic) bone marrow transplant or stem cell transplant * Recipients of blood transfusion within 30 days prior to study blood draw * Poor health status or unfit to tolerate blood draw