Evaluating the Efficacy of Resveratrol Containing Mouthwash as Adjunct Treatment Periodontitis:

Early Phase 1UnknownNCT05874882

University of Baghdad40 enrolled

Overview

To evaluate the effectiveness of resveratrol mouthwash as adjunct to NSP treatment of periodontitis

* Measuring and comparing the efficacy of RV mouth wash in comparison with CHX and placebo mouth wash in improving the clinical periodontal parameters; * Measuring the salivary cytokines (IL-6) before and after 4weeks of the use of RV mouth wash as adjunct to NSP treatment in comparison with other mouthwash by using enzyme-linked immunosorbent assay. * Measuring the salivary RANKL before and after 4weeks of the use of RV mouth wash as adjunct to NSP treatment in comparison with other mouthwash by using enzyme-linked immunosorbent assay. * Correlate the salivary cytokines IL-6 and salivary RANKL with clinical periodontal parameter and with each other. * Evaluate the intervention by using Visual analog scale (VAS)- score-based questionnaire will be filled out by each participant at the end of the trial.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE

Enrollment

Conditions

Periodontitis

Interventions

resveratrol mouthwash as adjunct to scaling and root planing in periodontitis patientsOTHER

patients with periodontitis will receive scaling and rootplaning and a resveratrol mouthwash twice daily for 4 weeks. saliva will be collected at the 1st visit and after one month then biochemical analysis for inflammatory biomarker will be done. periodontal parameters also will be evaluated at the 1st visit and after 1 month

chlorhexidine mouthwash as adjunct to scaling and root planing in periodontitis patientsOTHER

patients with periodontitis will receive scaling and rootplaning and a chlorhexidine mouthwash twice daily for 4 weeks. saliva will be collected at the 1st visit and after one month then biochemical analysis for inflammatory biomarker will be done. periodontal parameters also will be evaluated at the 1st visit and after 1 month

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: \- The inclusion criteria: 1. Participants need to be systemically healthy with age \> 18 years old. 2. Not taking antibiotic and anti-inflammatory drugs in the last three months. 3. At least 20 teeth should be present 4. Should have unstable periodontitis (PPD ≥ 5 or BOP at 4mm pocket) The exclusion criteria: 1. Patients wearing fixed prosthesis (crowns, bridges or orthodontic appliances) 2. Those with chronic disease, immunocompromised patients, pregnant, on contraceptives or lactating women. 3. Those currently using any mouthwash. 4. Those on antibiotic therapy and anti-inflammatory medications during the study and in the last 3 months before the study. 5. Those having a history of hypersensitivity to any product used in the present study. 6. Those who are smokers or alcoholics. 7. Those who refuse to participate in the trial. \-

Locations (1)

College of Dentistry

Baghdad, None Selected, Iraq

RECRUITING

Outcomes

Primary Outcomes

bleeding on probing

Time frame: at1 month from the baseline

Central Contacts

Hadeel MA [hakram], master

CONTACT

07703991957 hadeel.mazin@codental.uobaghdad.edu.iq

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.