Healing Process and Blood Sugar Level Following Local Anesthetic Infiltration With and Without Vasoconstrictor

Minia University40 enrolled

Overview

Evaluating the healing of the extraction socket and the glycemic levels before, and after injection of local anesthesia with and without vasoconstrictor in diabetic patients

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Diabetes Anesthesia, Local

Interventions

Local anaesthesia with vasocontrictor (Mepivacaine hydrochloride 20 mg (2%) + Levonordefrin hydrochloride 0.06 mg)DRUG

Mepivacaine hydrochloride 20 mg (2%) + Levonordefrin hydrochloride 0.06 mg

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Inclusion criteria patients over 20 years and under 60 years of age * DM controlled by medication * Requiring a tooth extraction in the maxilla, with an indication of the intra-alveolar technique for periodontal reasons. * Only participants that are willing to control and record blood glucose level throughout the study period. Exclusion Criteria: * Patients with any significant medical condition (besides DM) * Alcoholic individuals * Patients on drugs that affect the central nervous systems * Patients who reported the use of drugs that might interfere with pain sensitivity * Pregnant and lactating women * Patients with hypersensitivity to local anesthetics or non-steroidal anti-inflammatory drugs (NSAIDs).

Locations (1)

Faculty of Dentistry, Minia University

Minya, Egypt

Outcomes

Primary Outcomes

Glycemic level recorded before local anesthesia administration and 30 minutes following local anesthesia injection using glucometer

Time frame: 30 minutes

Secondary Outcomes

Healing score of the extraction socket

4 = Necrotic Tissue (Eschar): black, brown, or tan tissue that adheres firmly to the wound bed 3 = Slough: yellow or white tissue that adheres to the wound bed 2 = Granulation Tissue: pink or beefy red tissue with a shiny, moist, granular appearance. 1 = Epithelial Tissue: for superficial ulcers, new pink or shiny tissue that grows in from the edges or as islands on the wound surface. 0 = Closed/Resurfaced: the wound is completely covered with epithelium.

Time frame: 21 days

Data from ClinicalTrials.gov

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