This clinical trial tests the effect of tobacco flavor and liquid composition on the way a person puffs on a vape (topography). In general, tobacco products are designed with sensory factors in mind, such as flavor, to increase the appeal. Flavors and the composition of nicotine, either made in a lab (synthetic) or from tobacco, may create positive sensory effects, such as look, feel and taste, and influence smoking behavior and willingness to try different types of cigarettes. Understanding how nicotine vaping products are used is important in assessing individual and population level health risks. Vape flavors and synthetic nicotine may be related to harmful effects on health from vaping and may impact the appeal, risk beliefs and vaping topography.
PRIMARY OBJECTIVE: * Examine the influence of tobacco flavoring composition on vaping topography. * Examine the influence of synthetic versus (vs.) tobacco derived nicotine on vaping topography. SECONDARY OBJECTIVE: * Examine the influence of tobacco flavoring composition on vaping topography. * Examine the influence of synthetic versus (vs.) tobacco derived nicotine on vaping topography. OUTLINE: The order of directed and ad libitum bouts are randomized within participants at each session. SESSION 1: Participants puff their own brand liquid on study. SESSIONS 2-5: Participants puff 1 of 4 randomly assigned tobacco flavor formulations at each visit on study. SESSIONS 6-7: Participants puff 1 of 2 randomly assigned nicotine formulations at each visit on study. Participants also undergo collection of saliva samples and optionally undergo collection of oral cell and oral rinse samples throughout study.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
21
Undergo vape puffing regimen
Undergo collection of saliva samples and oral cell samples
Administer Quesitonnaire
Roswell Park Comprehensive Cancer Center
Buffalo, New York, United States
Puff Topography: Puff Count
Measure of vaping topography counting total number of puffs.
Time frame: Single Session, Approximately 2 hours in duration
Puff Topography: Puff Duration (in Seconds)
Measure of vaping topography counting duration of puffs in seconds.
Time frame: Single Session, Approximately 2 hours in duration
Puff Topography: Inter Puff Interval (IPI)
Measure of vaping topography counting the interval between puffs in seconds.
Time frame: Single Session, Approximately 2 hours in duration
Puff Topography: Puff Volume
Measure of vaping topography measuring the volume per puff in ml.
Time frame: Single Session, Approximately 2 hours in duration
Puff Topography: Flow Rate
Measure of vaping topography measuring the rate of flow per puff in milliliters per second.
Time frame: Single Session, Approximately 2 hours in duration
Subjective Questionnaires of Product Evaluation
Will be assessed by Duke Sensory Scale
Time frame: Single Session, Approximately 2 hours in duration
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