The Predictive Value of Progesterone

N/AActive Not RecruitingNCT05876234

University Hospital, Ghent3,000 enrolled

Overview

To evaluate a 5 ng/ml serum progesterone (P4) threshold policy for the addition of subcutaneous (SC) P4 in artificially prepared frozen embryo transfer cycles treated with vaginal P4. We assess whether the addition of SC P4 rescues cycles with serum P4 \<5 ng/ml and we study the impact of not supplementing cycles with serum P4 \>5 ng/ml by comparing them with serum P4 cycles above the conventionally proposed cut-off of 10 ng/ml.

Study Type

OBSERVATIONAL

Enrollment

3,000

Conditions

Subfertility

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 47 Years

Medical Language ↔ Plain English

* Embryo transfer between March 1st 2021 and March 31st 2023 * Determination of progesterone on the day of embryo transfer

Locations (1)

Ghent University Hospital - Department of Reproductive Medicine

Ghent, Belgium

Outcomes

Primary Outcomes

Ongoing pregnancy rate

Fetal heart beat at ultrasound

Time frame: 11 to 13 weeks after last menstruation

Secondary Outcomes

Clinical pregnancy rate

Ultrasound visualisation of the gestational sac

Time frame: 6 to 8 weeks after last menstruation

Data from ClinicalTrials.gov

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