The purpose of this study is to assess whether post-exercise Greek yogurt following a single session of aerobic exercise improves metabolic and musculoskeletal health in women with overweight/obesity.
Following the acquisition of informed consent, eligibility to participate in the study will be determined using questionnaires. Participants will undergo baseline testing at our laboratory at the University of Toronto to determine cardiorespiratory fitness, body composition and undergo exercise familiarization. Eligible participants will be assigned, in a random order, to two metabolic trials approximately 4 weeks apart that involve 4 days of controlled diet and exercise. Each trial takes place over 4 days, but participants are not required to come to the laboratory on all days. The two trials involve: 1) Exercise + Greek Yogurt (GY) 2) Exercise + a carbohydrate-based study supplement (SS). During the 4 day trials, participants consume controlled diets and the study supplements (GY and SS). On 1 of these days participants will perform exercise in our lab followed by the consumption of GY or SS. Various outcomes will be measured throughout the trial, including glycemic control (via continuous glucose monitoring), fat oxidation, appetite and health outcomes in blood samples. Throughout the duration of the study, participants will be asked to maintain their habitual diet and physical activity patterns, and maintain their current body weight.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
20
Following 2 days of controlled diet, participants will consume greek yogurt following high-intensity interval exercise
Following 2 days of controlled diet, participants will consume a carbohydrate-based study supplement following high-intensity interval exercise
Following 2 days of controlled diet, participants will perform high-intensity interval exercise following an overnight fast
Jenna Gillen
Toronto, Ontario, Canada
Postprandial glycemia
Postprandial glucose exposure assessed using continuous glucose monitoring
Time frame: 24 hour post-exercise
24 hours average glucose
Average glucose concentration over 24 hours
Time frame: 24 hours post-exercise
Nocturnal glucose
Overnight glucose concentration
Time frame: 6-8 hours
Nocturnal glucose
Overnight glucose exposure (area under the curve)
Time frame: 6-8 hours
Glycemic variability
Continuous overall net glycemic action (CONGA)
Time frame: 24 hours
Glycemic variability
Standard deviation (SD)
Time frame: 24 hours
Glycemic variability
Coefficient of variation (%CV)
Time frame: 24 hours
Post-exercise fat oxidation
Fat oxidation assessed with indirect calorimetry
Time frame: 1, 2 and 3 hours post-exercise
Fasting glucose concentration
Venous blood sampling
Time frame: 24 hours post-exercise
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Fasting insulin concentration
Venous blood sampling
Time frame: 24 hours post-exercise
Fasting insulin resistance
Homeostasis Model Assessment (HOMA2)
Time frame: 24 hours post-exercise
Bone metabolism
Serum concentration of CTX
Time frame: 30, 90, and 180 minutes and 24 hours post-exercise
Bone metabolism
Serum concentration of OPG
Time frame: 30, 90, and 180 minutes and 24 hours post-exercise
Bone metabolism
Serum concentration of RANKL
Time frame: 30, 90, and 180 minutes and 24 hours post-exercise
Bone metabolism
Serum concentration of OC
Time frame: 30, 90, and 180 minutes and 24 hours post-exercise