Clinical and Radiographic Assessment of Nano-Bioactive Glass Combined With I-PRF Scaffold in Vital Pulp Treatments in Mandibular Molars With Closed Apices

Inclusion Criteria: * Patients suffering from Symptomatic irreversible pulpitis in mature mandibular molars only will be involved. * Tooth should give positive response to cold test * Haemostasias should be achieved after total pulpotomy * The tooth is restorable and free from advanced periodontal disease, cracks and splits. * Patients should be free from any systemic disease that may affect normal healing and predictable outcome. * Patients who will agree to the consent and will commit to follow-up period. * Patients with mature root apices * Patients with no internal or external resorption and no periapical lesions * Soft tissues around the tooth are normal with no swelling or sinus tract. Exclusion Criteria: * Patients with immature roots. * Haemostasias after 10 minutes can not be controlled after total pulpotomy * Patients with any systemic disease that may affect normal healing. * Patients with periapical lesions or infections. * Pregnant females. * Patients who could/would not participate in a 6 months follow-up. * Patients with fistula or swelling * Patients with necrotic pulp. * Patients with old age.