PEA in Functional Dyspepsia

Inclusion Criteria: * Patients with functional dyspepsia as diagnosed by the Rome IV criteria. * Subjects must provide witnessed written informed consent prior to any study procedures being performed. * Subjects aged 18-70 years old. * Male or female subjects. * Subjects who are capable to understand the study and the questionnaires, and to comply with the study requirements. * Women of child-bearing potential agree to apply a highly effective method of birth control during the entire duration of the trial. Highly effective birth control is defined as those which result in a low failure rate (i.e., less than 1% per year) when used constantly and correctly such as implants, injectables, combined oral contraceptive method, or some intrauterine devices (IUDs), sexual abstinence, or vasectomized partner. Women of non-childbearing potential may be included if surgically sterile (tubal ligation or hysterectomy) or postmenopausal with at least 2 year without spontaneous menses. Exclusion Criteria: * Presence of a history of gastrointestinal surgery other than appendectomy and cholecystectomy. * Organic gastro-intestinal disease * Major psychiatric disorder such as major depression * Presence of coeliac disease, lupus, scleroderma and other systemic auto-immune disease. * Patients with eosinophilic esophagitis * Presence of diabetes mellitus * Active H. Pylori infection or \< 6 months after eradication * Predominant IBS (based on the Rome IV questionnaire) * Predominant GERD (based on the Rome IV questionnaire) * Patients taking prohibited medication * Females who are pregnant or lactating * Patients not capable to understand or be compliant with the study.