Livedoid Vasculopathy: Strong Association With Smoking, Weak Association With Thrombophilia

University of Zurich15 enrolled

Overview

A screening of patient histories at the clinics of Dermatology of the universities of Zurich, Basel and Bern is performed in order to identify patients with a history of Livedoid vasculopathy. Patients with a history of livedoid vasculopathy are asked to participate in the study. After reading the patient information and if the informed consent is signed patients are included in the study. Patients are questioned about their smoking history and blood is drawn in order to perform a screening for thrombophilia.

A screening of patient histories at the clinics of Dermatology of the universities of Zurich, Basel and Bern is performed in order to identify patients with a history of Livedoid vasculopathy. Patients with a history of livedoid vasculopathy are asked to participate in the study. The presence of Livedoid vasculopathy must be confirmed by a histologic specimen. After reading the patient information and if the informed consent is signed patients are included in the study. Patients are questioned about their smoking history and blood is drawn in order to perform a screening for thrombophilia. The presence of a history of smoking and thrombophilia is compared to the general Swiss population.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Livedoid Vasculitis

Interventions

Thrombophilia screeningOTHER

No intervention. Blood is drawn for analysis.

Eligibility

Sex: ALLMin age: 10 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * History of livedoid vasculopathy Exclusion Criteria: * Diagnosis was not proved by biopsy specimen * A different reason than livedoid vasculopathy has been found for the symptoms of the patient * No informed consent by the patient

Locations (3)

University hospital of Basel

Basel, Switzerland

University hospital of Bern

Bern, Switzerland

University hospital Zurich

Zurich, Switzerland

Outcomes

Primary Outcomes

Smoking history: Patients will be asked if they currently smoke or if they are former smokers. If one of both items is yes, it means a positive answer.

The primary endpoint is the comparison of a positive smoking history and other cardiovascular risk factors of patients with livedoid vasculopathy with the Swiss general population.

Time frame: 22 months

Secondary Outcomes

Thrombophilia screening: the following parameters will be determined in every participant: Factor V Leiden, Prothrombin 20210; Protein C, Protein S, Antithrombin III, Beta 2 Glykoprotein 1, Lupus Antikoagulans

The secondary endpoint is the search for thrombophilia in patients with livedoid vasculopathy.

Time frame: 22 months

Data from ClinicalTrials.gov

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