This phase III trial compares the effect of methylene blue mouthwash to standard of care mouthwash for the treatment of oral mucositis pain in patients with cancer. Using methlylene blue mouthwash may improve oral pain in patients with oral mucositis related to cancer and/or cancer treatments compared to usual standard of care.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
49
Given PO
Mayo Clinic in Rochester
Rochester, Minnesota, United States
Change in oral pain
Pain will be assessed using the standard institutional numeric rating scale where pain level is quantified on a scale of 0 (no pain) to 10 (worst possible pain) pre- and post-intervention (3 times daily for 3 days). Last collected scores will be compared to baseline.
Time frame: Baseline, 3 days
Change in the amount of oral intake
Electronic medical records will be reviewed for demographic and clinical information, medication administration record, and intake and output
Time frame: Baseline, 3 days
Change in the amount of daily requirements of oral morphine equivalents
Electronic medical records will be reviewed for demographic and clinical information, medication administration record, and intake and output
Time frame: Baseline, 3 days
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