The goal of this individual patient data meta-analysis is to estimate the attributed and the associated health burden related to bloodstream infections, pneumonia, skin and soft tissue infections, surgical site infections and urinary tract infections, caused by target drug-resistant pathogens, in high income countries. The main question\[s\] it aims to answer are: * Are common infections caused by drug-resistant pathogens associated with an increased health burden, when compared with individuals with the same infection caused by a susceptible strain (attributed burden)? * Are common infections caused by drug-resistant pathogens associated with an increase health burden, when compared with individuals without the infection under study (associated burden)?
Study Type
OBSERVATIONAL
Enrollment
5,000
Drug resistant phenotype of the target pathogen under study
Hospital Universitario Virgen Macarena
Seville, Spain
Mortality
Death any time after infection, during the follow-up time of the original study.
Time frame: Through study completion, an average of 1 year
Number of participants with ICU admission
Need for an admission in ICU setting for more than 24 hours after infection onset.
Time frame: Through study completion, an average of 1 year
Number of participants with clinical cure
Absence of symptoms after completion of an antibiotic treatment course.
Time frame: Through study completion, an average of 1 year
Number of participants with microbiological cure
No isolation of the causal microorganisms after completion of an antibiotic treatment course.
Time frame: Through study completion, an average of 1 year
Number of participants with recurrence of infection
Infection with the same organism after more than two weeks of the initial infection.
Time frame: Through study completion, an average of 1 year
Number of participants with superinfection
Other infections different from the one under assessment.
Time frame: Through study completion, an average of 1 year
Number of participants with cognitive impairment / disability
Impairment is any temporal or permanent loss of function; disability is a restriction or inability to perform a normal activity resulting from an impairment. Assessed using Center for Epidemiologic Studies Depression Scale (CES-D), Mini-Mental State Examination (MMSE) or Trail Making Test (TMT).
Time frame: Through study completion, an average of 1 year
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