Multimodality Cardiovascular Imaging for the Translation of Therapies for Vascular Activation After MI

Inclusion Criteria: * Acute type I myocardial infarction (NSTEMI or STEMI) * Reperfusion therapy planned or performed within prior 48 hrs * Carotid or femoral artery plaque at baseline, or carotid intima media thickness \>1.5 mm Exclusion Criteria: * Type II MI * Failed primary PCI or need for emergent bypass surgery * Severe heart failure (NYHA class IV) * Life-threatening complication of MI (myocardial rupture, ischemic VSD, papillary muscle rupture) * Refractory ventricular arrhythmias * Allergy to dapansutril, OLT177, or drugs in the same class * Co-morbidity limiting 6 month survival * Active malignancy or recent malignancy with any systemic anti-cancer treatment * Active infection * Use of immunosuppressive medications or immunodeficiency disorder * Neutropenia (ANC \<2,000) * Moderate or severe renal impairment (GFR \<30 ml/min) * Recent stroke (within previous 3 months) * Allergy to ultrasound enhancing agents or polyethylene glycol * Pregnancy or breastfeeding