The goal of this clinical trial is to compare the efficacy, safety and feasibility of intravenous Fosaprepitant and Ondansetron for the prevention of postoperative nausea and vomiting in thoracicsurgery patients. Participants will be randomized in a 1:1 ratio to the Fosaprepitant and Ondansetron group.The groups were analyzed and compared for frequency of vomiting in 24 h after surgery. In addition, we will further compare the occurrence of postoperative pulmonary complications, length of hospital stay, nutrition and quality of life after surgery in patients treated with different antiemetic prophylaxis.
Postoperative nausea and vomiting (PONV) is a common postoperative complication of general anesthesia. The antiemetic 5-serotonin 3 (5-HT 3) receptor antagonist is widely used in postoperative anti-emesis,However, more clinical studies are needed to confirm whether neurokinin-1 (NK-1) receptor antagonists have better effects on PONV than 5-HT 3 receptor antagonists.We aimed to evaluate the effects of NK-1 receptor antagonists and 5-HT 3 receptor antagonists on PONV through a randomized controlled study. To this end, we took patients undergoing thoracic surgery as the research object, they received an antiemetic prophylaxis with ondansetron or fosaprepitant, and the frequency of postoperative nausea and vomiting the of the two antiemetic prophylaxis regimens were analyzed, and the occurrence of pulmonary complications, length of hospital stay, the nutrition and quality of life after surgery administration were also compared. Through this clinical trial, we hope to obtain a better antiemetic prophylaxis regimen and provide clear information for patients and physicians to guide clinical decisions that enhance treatment efficacy and reduce the occurrence of side effects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
234
8 mg Ondansetron+100 ml normal saline
150 mg fosaprepitant +100 ml normal saline
Incidence of PONV within 24 hours
The groups will be analyzed and compared for frequency of nausea and vomiting in 24 h after surgery
Time frame: Day 1
Incidence of PONV within 48 hours
The groups will be analyzed and compared for frequency of nausea and vomiting in 48 h after surgery
Time frame: Day 2
occurrence of Drug-related adverse effects
The groups will be compared for the incidence of unwanted effects of antiemetic medicines include onstipation,weakness, headache, dizziness and sleepiness.
Time frame: Day 3
Postoperative pain score
This project will be measured by patients' postoperative pain score.
Time frame: Day 3
The dosage of opioids used after surgery
This project will be measured by the dosage of opioid drugs used after surgery.
Time frame: Day 3
the length of hospital stay
The groups will be compared for the time from admission to discharge
Time frame: From date of admission until the date of discharge, assessed up to 7 days.
postoperative pulmonary complications
Postoperative pulmonary complications include respiratory infection,respiratory failure,pleural effusion,atelectasis and pneumothorax
Time frame: Day 3
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