Effect of Sulthiame on EEG in Childhood Epilepsy Syndromes

University Hospital, Angers15 enrolled

Overview

The effect of sulthiame on EEG has been studied in epilepsy syndromes of childhood with sleep activation by comparing sleep EEG obtained at baseline and after 4 weeks of treatment. The aim of the study is to know if an effect is still identifiable after 2 weeks of treatment by performing sleep EEG recordings after 2 and 4 weeks of treatment, respectively.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Importance of Interictal Epileptiform Activity on Sleep EEG Epilepsy in Children

Interventions

SulthiameDRUG

Sulthiame add-on according to good clinical practice in these childhood epilepsy syndromes

Eligibility

Sex: ALLMin age: 6 YearsMax age: 15 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of epilepsy syndromes of childhood with sleep activation * Failure of at least two anti-epileptic drugs (AED) * Sleep EEG performed in the last 7 days before inclusion and showing interictal epileptiform discharges (baseline EEG) Exclusion Criteria: * Previous trial with sulthiame * More than 2 AED at inclusion * Use of corticosteroids at inclusion * Change in the anti-epileptic treatment in the 7 days before baseline EEG

Locations (3)

Angers University Hospital, Pediatric department

Angers, France

RECRUITING

Strasbourg University Hospital, Pediatric department

Strasbourg, France

NOT_YET_RECRUITING

Toulouse University Hospital, Pediatric Neurology Department

Toulouse, France

NOT_YET_RECRUITING

Outcomes

Primary Outcomes

Percentage of patients showing improved sleep EEG at day 14 compared to baseline EEG

Time frame: 14 days

Central Contacts

Patrick Van Bogaert, Professor

CONTACT

02.41.35.48.46 Patrick.VanBogaert@chu-angers.fr

Elsa Berardi

CONTACT

Data from ClinicalTrials.gov

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