Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBD) with a heterogeneous disease course. Recurrent mucosal inflammation or chronic subclinical inflammation results in damage to the bowel and complications like stenosis, fistula and colorectal cancer. Therefore, tight control of mucosal inflammation is important to prevent complications. The goal of this multicenter observational cohort study is to determine the best remote monitoring tool for predicting mucosal inflammation in adult patients with inflammatory bowel disease, relative to the gold standard endoscopy. Participants will be asked to fill out questionnaires regarding disease activity (MIAH, mHI, IBD-control, Manitoba IBD Index, p-HBI/p-SCCAI), perform a FC home test and collect one stool sample for routine laboratory calprotectin measurement, before the start of the bowel preparation for the ileocolonoscopy. During this ileocolonoscopy, endoscopic disease activity will be determined. .
Study Type
OBSERVATIONAL
Enrollment
400
MIAH, mHI, Manotiba IBD Index, p-HBI/SCCAI, IBD-control
fecal calprotectin point-of-care test and laboratory test
endoscopic activity scores (SES-CD, UCEIS, MES)
Jeroen Bosch Hospital
's-Hertogenbosch, Netherlands
RECRUITINGCatharina Hospital Eindhoven
Eindhoven, Netherlands
NOT_YET_RECRUITINGMaastricht University Medical Centre
Maastricht, Netherlands
RECRUITINGFranciscus Gasthuis&Vlietland
Rotterdam, Netherlands
RECRUITINGZuyderland Medical Centre
Sittard, Netherlands
NOT_YET_RECRUITINGPrediction of mucosal inflammation in daily clinical practice with PROMs and FC home test
Time frame: week 0 (i.e. in the week before the colonoscopy)
Recalibration of PROMs
Recalibrate PROMs with the FC home test to optimise prediction of mucosal inflammation, relative to the gold standard ileocolonoscopy, for use in daily clinical practice
Time frame: week 0 (i.e. in the week before the colonoscopy)
prediction of mucosal inflammation in strict trial setting with PROMs and FC home test
Time frame: week 0 (i.e. in the week before the colonoscopy)
Agreement between FC home test and routine laboratory tests
Time frame: week 0-1 (i.e. FC home test in the week before the colonoscopy and the laboratory test at the day of the colonoscopy)
Association between clinical (abdominal pain) and histologic disease activity
Time frame: week 0-1
Association between IBD-control and histologic disease activity
Time frame: week 0-1
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