Comparison of PRP & DFDBA vs. DFDBA in Intrabony Periodontal Defects

Government Dental College and Hospital, India13 enrolled

Overview

The purpose of this clinical trial is to compare the results in subjects with periodontitis using subjects own blood - Platelet-rich plasma (PRP) combined with bone graft material, namely, Demineralized Freeze - Dried Bone Allograft (DFDBA) or DFDBA alone in the treatment of bone defects around the teeth.

After being informed about the study and potential risks, 13 patients giving written informed consent and who meet the eligibility requirements were randomly allocated in a single blind manner (participants) to test group (PRP combined with DFDBA) or control group (DFDBA). 33 sites (18 test, 15 control unpaired defects) were treated - 1) to investigate the possible additional effects of PRP when combined with DFDBA, and 2) to compare the clinical and radiographic outcomes obtained in test and control groups,12 months post - operatively.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Chronic Periodontitis

Interventions

PRP combined with DFDBAOTHER

Periodontal intrabony defects were treated with open flap debridement followed by placement of PRP combined with DFDBA

DFDBAOTHER

Periodontal intrabony defects were treated with open flap debridement followed by placement of PRP combined with DFDBA

Eligibility

Sex: ALLMin age: 28 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Outpatients * with chronic periodontitis * who were free of local or systemic disease * who had not received any type of periodontal therapy in the last six months * radiograph showing at least one angular defect in any quadrant * the involved teeth were vital and asymptomatic * the site of interest had at least 2 mm of keratinized gingiva on the facial aspect of the selected teeth Exclusion Criteria: * Patients with abnormal platelet count * allergic to chlorhexidine or any other medicine used in the study * showing unacceptable oral hygiene compliance during / after the phase I therapy; * pregnant or lactating mothers; * smokers * endodontically involved teeth * patients under any medication known to interfere with periodontal healing. e.g., corticosteroids * on anticoagulant therapy * patients with transferable jobs or who were uncooperative * patients participating in other dental clinical trials.

Locations (1)

212, Department of Periodontology, Government Dental college and Hospital

Nagpur, Maharashtra, India

Outcomes

Primary Outcomes

Change in Probing Pocket Depth (PPD) from baseline to 12 months

PPD is vertical measurement from the free gingival margin to the base of the pocket measured to the nearest millimeter using a UNC (University of North Carolina) -15 periodontal probe.