Comparison of Co2 Laser Versus Co2 Laser With PRP in Scars

Combined Military Hospital Abbottabad60 enrolled

Overview

Objective: To compare the effect of Fractional Carbon dioxide Laser (FCL) Vs Fractional Carbon dioxide Laser with platelet rich plasma (PRP) in management of Scars. Study design: Randomized-controlled trial (RCT). Study setting and duration: Dermatology Department, CMH-Abbottabad, November 2022/April 2023. Methodology: The sample size of 60 patients, age 18 to 50 years, was calculated by using Openepi app and the non-probability consecutive sampling technique was used. Patient in group A received FCL treatment's four sessions with four weeks apart, whereas Group B received four PRP and FCL sessions. The Quartile grading scale (score 0 is \<25%, score 1 is 25-50%, score 2 is 51-75% and score 3 is \>75% improvement) was used to assess the patient's clinical improvement at 4 weeks after each session. To determine statistical significance χ2-square test, taking p-value \<0.05 as significant, was used.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

CO2 Laser in Scars

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged 18-50 years * Fitzpatrick skin type III-V * Presented with post-acne, post traumatic or post burn scars * all those patients emotionally balanced with realistic expectations were included in the study. Exclusion Criteria: * scar that was less than 6 months old * if they had an active infection or inflammatory skin condition * having a history of malignancy * a known connective tissue illness * history of excessive bleeding or keloids * unrealistic expectations * pregnant or breastfeeding.

Outcomes

Primary Outcomes

Quartile grading scale for assessment of scars

Quartile grading scale was used to assess effectiveness of CO2 laser and CO2 laser with Platelet rich plasma in scars.Minimum score=0,Maximum Score=3 .Maximum score means better outcome.The Quartile grading scale (score 0 is \<25%, score 1 is 25-50%, score 2 is 51-75% and score 3 is \>75% improvement) was used to assess the patient's clinical improvement at 4 weeks after each session.

Time frame: 16 weeks