Prostate-specific membrane antigen (PSMA) is a type II transmembrane glycoprotein that consists of 750 amino acids. It is highly expressed on most prostate cancer cells and neovascular endothelial cells of tumors, making PSMA a highly specific and significant imaging target for malignancies. \[68Ga\]P3, a novel molecular probe of PET imaging agent that targets PSMA, can be used in the diagnosis and research of a wide variety of PSMA high-expression malignanciesr.
Prostate-specific membrane antigen (PSMA) is a type II transmembrane glycoprotein that consists of 750 amino acids. It is highly expressed on most prostate cancer cells and neovascular endothelial cells of tumors, making PSMA a highly specific and significant imaging target for malignancies.\[68Ga\]P3, a novel molecular probe of PET imaging agent that targets PSMA, can be used in the diagnosis and research of a wide variety of PSMA high-expression malignanciesr.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
350
68Ga-P3 is injected intravenously with a dose of 0.06-0.08 mCi/kg.
Peking University First Hospital
Beijing, Beijing Municipality, China
RECRUITINGThe diagnostic efficacy of 68Ga-P3 PET/CT in the evaluation of malignant tumors
Compare the standardized Uptake Value (SUV) of lesions on 68Ga-P3 and 18F-FDG PET/CT
Time frame: 1 year
The detection efficacy of 68Ga-P3 PET/CT in the evaluation of malignant tumors
Compare the number of lesions detected by 68Ga-P3 and 18F-FDG PET/CT, based on the pathology or clinical follow-up as gold standard.
Time frame: 1 year
The dosimetry of 68Ga-P3
Research on the dose distribution of 68Ga-P3 in healthy volunteers and cancer patients by 1-hour dynamic PET/CT acquisition and analyze by the dosimetry software
Time frame: 1 year
Quantitative evaluation of 68Ga-P3
Evaluation of quantitative parameters of 68Ga-P3, such as time-activity curve.
Time frame: 1 year
Correlation with pathological expression
Analyze PSMA expression at the imaging level in combination with PSMA expression in pathological specimens
Time frame: 1 year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.