Study to Evaluate the Efficacy, Safety and Tolerability of 3% LTX-109 for Nasal Decolonisation of Staphylococcus Aureus

Inclusion Criteria: * Willing and able to give written informed consent for participation in the study. * Male or female subject aged 18 to 65 years, inclusive. * Persistent nasal carrier of S. aureus (MSSA), confirmed by 2 positive bacterial cultures from the nose during the screening period. * Medically healthy subjects without abnormal clinically significant medical history, physical findings, vital signs, or laboratory values at the time of screening, as judged by the Investigator. * Women of child bearing potential (WOCBP) had to practice abstinence (only allowed when this was the preferred and usual lifestyle of the subject) or had to agree to use a highly effective method of contraception with a failure rate of \< 1% to prevent pregnancy from the date of dosing until 2 weeks after last dose. Female subjects had to refrain from donating eggs from the date of dosing until 3 months after dosing with the IMP. Their male partner had to agree to use a condom from date of first dosing until 2 weeks after last dose if he had not undergone vasectomy. Male subjects had to be willing to use condom or had to be vasectomised or practice sexual abstinence to prevent pregnancy and drug exposure of a partner and had to refrain from donating sperm from the date of dosing until 3 months after dosing with the IMP. Their female partner of child-bearing potential had to use contraceptive methods with a failure rate of \< 1% to prevent pregnancy (see above). Exclusion Criteria: * History of any clinically significant disease or disorder which, in the opinion of the Investigator, could either put the subject at risk because of participation in the study, or influence the results or the subject's ability to participate in the study. * Any clinically significant illness, medical/surgical procedure or trauma within 4 weeks of the administration of IMP. * Severe eczema or skin wounds, dry or sensitive skin assessed as clinically significant by the Investigator. * Any positive result at screening for serum hepatitis B surface antigen, hepatitis C antibody and HIV. * History of severe allergy/hypersensitivity or ongoing allergy/hypersensitivity, as judged by the Investigator, or history of hypersensitivity to drugs with a similar chemical structure or class to LTX-109 or chlorhexidine. * S. aureus (MSSA and/or MRSA) decolonisation attempt in the 6 months prior to - MRSA positive at screening (Visit 1 and/or Visit 2). * Inability to take medications nasally. * Nasal polyps or significant anatomical nasal abnormality, as judged by the Investigator. * Evidence of open wound, lesion, inflammation, erythema or infection (including active rhinitis, sinusitis or upper respiratory infection or severe acne vulgaris) affecting the nostril area, lip and skin close to the nose. * History of multiple episodes (\>3) of epistaxis within 12 months prior to screening Visit 2. * Disease in the region of the application sites, significant history of trauma or skin disease in the region of the application sites, current nasal skin or nasal septum condition requiring treatment or nasal surgery in the 6 months prior to screening Visit 2. * In situ nasal jewellery or open nasal piercings. * Previous or concurrent treatment with antimicrobials for an infection within the last 28 days prior to the first administration of IMP.