In last decades, a change in dietary habits has been observed in industrialized countries characterized by a drastic increase in the consumption of ultra-processed foods (UPF, Ultra-Processed Foods). As defined by the NOVA classification, UPFs are industrial formulations of food substances added with colourings, flavourings, emulsifiers, thickeners and other additives. Among the main compounds of UPFs are the advanced glycation end-products (AGEs). Increasing evidence suggests an association between dietary exposure to AGEs and the development of chronic non-communicable diseases, such as obesity and allergies, in the general population, through increased oxidative stress and inflammation. Preliminary evidence suggests that a maternal diet rich in AGEs during pregnancy and lactation could negatively influence the composition of breast milk and have a negative impact on the infants health. However, data regarding the presence of derivatives of UPFs in breast milk are not available. The UFIM (Ultraprocessed Foods In Breast Milk) study aims at evaluate the presence of UPFs-derivatives compounds in breast milk.
Study Type
OBSERVATIONAL
Enrollment
300
Department of Traslational Medical Science - University of Naples Federico II
Naples, Italy
RECRUITINGTo evaluate the presence of the major UPFs-derived compounds AGEs in breast milk
Through the liquid chromatography with triple quadrupole mass spectrometric detection techniques (LC-MS/MS) will be assessed the quantity of AGEs in breast milk.
Time frame: 36 months
Dietary intake of UPF in lactating women
A 7-day food diary will be used for the evaluation of UPF dietary intake through the NOVA classification system.
Time frame: 36 months
Dietary intake of AGEs in lactating women
A 7-day food diary will be used for the evaluation of AGEs dietary intake through a reference database reporting the presence of AGEs in food.
Time frame: 36 months
Skin AGEs accumulation levels in lactating women
The non-invasive device AGEs reader will be used to evaluate the skin AGEs accumulation levels in lactating women.
Time frame: 36 months
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